摘要
目的 探究利培酮联合艾司西酞普兰治疗双相情感障碍抑郁发作的疗效及对血清尿酸(UA)的影响。方法 选取在我院2020年7月至2023年10月收治的108例双相情感障碍抑郁发作患者,随机分为A组(n=54)和B组(n=54)。A组服用艾司西酞普兰进行治疗,B组服用利培酮联合艾司西酞普兰进行治疗,比较两组患者的临床总体印象(CGI)评分、临床疗效、病情改善时间、汉密尔顿抑郁量表(HAMD)评分、UA以及不良反应发生率。结果 B组的治疗总有效率(90.74%)显著高于A组(74.07%)(P<0.05);治疗后B组CGI评分低于A组(P<0.05);B组病情改善时间显著短于A组(P<0.05);两组各时间点的HAMD评分、UA水平随时间的变化趋势逐渐降低(P<0.05);治疗后B组患者各时间点HAMD评分、UA水平显著低于A组(P<0.05)。两组不良反应发生率比较差异无统计学意义(P>0.05)。结论 利培酮联合艾司西酞普兰治疗双相情感障碍抑郁发作患者疗效显著,可显著降低UA水平,在临床治疗双相情感障碍抑郁发作方面具有重要价值。
Objective To investigate the efficacy of risperidone combined with escitalopram in treating depressive episode of bipolar disorder and its impacts on serum uric acid(UA).Methods From July 2020 to October 2023,total 108 depressive episode of bipolar disorder patients who visited our hospital were randomly grouped into group A(n=54)and group B(n=54).Group A received treatment with escitalopram,while group B received treatment with risperidone combined with escitalopram.Clinical Global Impression(CGI)score,clinical efficacy,improvement time of the condition,Hamilton Depression Scale(HAMD)score,UA,and incidence of adverse reactions were compared.Results Total effective rate in group B(90.74%)was greatly higher than that in group A(74.07%)(P<0.05).After treatment,CGI score of Group B was lower than that of Group A(P<0.05).The improvement time of the condition in group B was greatly shorter than that in group A(P<0.05).Changes in HAMD score,UA at different time points gradually decreased over time(P<0.05).After treatment,HAMD score,UA in group B were greatly lower than those in group A at various time points(P<0.05).Conclusion The combination of risperidone and escitalopram has a great therapeutic effect on depressive episode of bipolar disorder patients,it could greatly reduce UA,and has important value in clinical treatment of depressive episode of bipolar disorder.
作者
尚保华
胡佳
张刚
杨晓玲
Shang Baohua;Hu Jia;Zhang Gang;et al(Department of Psychiatry II,Department of Clinical Laboratory,the Eighth Hospital of Shijiazhuang,Shijiazhuang,Hebei 050000,China)
出处
《四川医学》
2025年第8期900-903,共4页
Sichuan Medical Journal
