摘要
Tuberculosis(TB)infection,caused by Mycobacterium tuberculo-sis,reveals tens of millions of new cases and causes millions of deaths each year.The traditional clinical treatment for TB is long-term and combined usage of antibiotics but suffers from poor lesion and pathogen targeting,insufficient efficacy,high systemic toxicity,and ineffectiveness against drug-resistant M.tuberculosis.As a characteristic lesion of TB,granulomas have a compact construction,which greatly limits the access of small-molecule antibiotics to the necrotic area to kill M.tuberculosis[1].
