摘要
目的分析血清β2-微球蛋白(β2-microglobulin,β2-MG)、视黄醇结合蛋白(retinol binding protein,RBP)及尿酸(uric acid,UA)、糖化血红蛋白(glycated hemoglobin A1c,HbA1c)在糖尿病肾病(diabetic nephropa‐thy,DN)早期诊断中的应用价值。方法回顾性选取2021年1月—2024年10月肥城市中医医院收治的40例早期糖尿病肾患者的临床资料作为DN组,另选取同期40例健康体检者作为对照组。比较两组β2-MG、RBP及UA、HbA1c指标水平,分析联合检测的诊断价值。结果DN组血清β2-MG、RBP、UA、HbA1c水平均高于对照组,差异均有统计学意义(P均<0.05)。血清β2-MG、RBP、UA、HbA1c联合检测诊断DN的AUC为0.937,95%CI:0.886~0.988,灵敏度为0.875,特异度为0.850。结论联合检测血清β2-MG、RBP及UA、HbA1c能够显著提高DN患者早期的诊断效率,具有较高的临床应用价值。
Objective To analyze the value of serumβ2-microglobulin(β2-MG),retinol binding protein(RBP),uric acid(UA)and glycosylated hemoglobin A1c(HbA1c)in the early diagnosis of diabetes nephropathy(DN).Methods The clinical data of 40 patients with early diabetic kidney admitted to Feicheng Hospital of Traditional Chinese Medi‐cine from January 2021 to October 2024 were retrospectively selected as the DN group,and 40 healthy subjects in the same period were selected as the control group.The levels ofβ2-MG,RBP,UA and HbA1c were compared between the two groups.The diagnostic efficacy of combined detection was analyzed.Results The levels of serumβ2-MG,RBP,UA and HbA1c in the DN group were higher than those in the control group,and the differences were statisti‐cally significant(all P<0.05).The AUC of combined detection of serumβ2-MG,RBP,UA and HbA1c for DN was 0.937,95%CI:0.886-0.988,sensitivity was 0.875,and specificity was 0.850.Conclusion The combined detection of serumβ2-MG,RBP,UA,and HbA1c can significantly improve the early diagnostic efficiency of DN patients and has high clinical application value.
作者
王伟
左秀云
WANG Wei;ZUO Xiuyun(Department of Clinical Laboratory,Feicheng Hospital of Traditional Chinese Medicine,Feicheng 271600,Shandong,China)
出处
《糖尿病新世界》
2025年第12期61-63,70,共4页
Diabetes New World
