摘要
The blood-brain barrier(BBB)is a substantial impediment to effectively delivering central nervous system(CNS)therapies.In this review,we provide a compre-hensive dissection of the BBB's elaborate structure and function and discuss the inherent limitations of conventional dnug delivery mechanisms due to its imper-meability.We summarized the creativedeployment of nanocarriers,the astute modification of small molecules to bolster theirCNS penetration capabilities as well as the burgeoning potential of magnetic nanoparticles and optical techniques that are positioned to enable more precise and targeted drug delivery across the BBB and we discuss the current clinical application of some nanomedicines.In addition,we emphasize the indispensable role of artificial intelligence in designing novel materials and the paramount significance of interdisciplinaryresearch in surmounting clinical challenges associated withBBBpenetration.Our review meticulously integrates these insights to accentuate the impact of nano-technological innovations in BBB research and CNS disease management.It presents a promising trajectory for the evolution of patient care in neurological disorders and suggests that these scientific strides could lead to more efficacious treatments and improved outcomes for those afflicted with such conditions.
基金
support from National Natural Science Foundation of China(22077038 and 52325304)
Wuhan Science and Technology Bureau Shuguang Project Fund(NO.2022020801020592)
Wuhan Pulmonary Hospital Fund(NO.YNZZ2203)
support of the Texas Engineering Experiment Station(TEES)through a professorship to AG-E(TEES-246413).
