摘要
脑缺血再灌注损伤(cerebral ischemia-reperfusion injury,CIRI)表现为缺血脑组织恢复血流后供血区域继发性损伤加重。作为当前研究广泛的炎症小体,核苷酸结合寡聚化结构域样受体蛋白3(nucleotide-binding oligomerization domain-like receptor protein 3,NLRP3)参与CIRI病理进程,其激活可触发强烈炎症级联反应并诱导神经细胞死亡。鉴于此,本文将综述NLRP3炎症小体的结构特征、信号转导通路、在CIRI中的作用机制及药物干预策略,以期为中医药防治CIRI提供参考资料。
Cerebral ischemia-reperfusion injury(CIRI)is a pathological condition characterized by the aggra‑vation of the secondary injury in the brain region previously deprived of blood supply upon the restoration of blood flow.nu‑cleotide-binding oligomerization domain-like receptor protein 3(NLRP3),a pivotal inflammatory complex,plays an inte‑gral role in the pathophysiology of CIRI.Its activation can instigate a robust inflammatory cascade,culminating in nerve cell death.In light of these insights,this paper reviews the structural characteristics,signaling transduction pathways,and mechanistic involvement of NLRP3 in CIRI.Additionally,the drug intervention strategies targeting inflammatory cor‑puscles are discussed,with the aim of providing reference materials for the prevention and treatment of CIRI by traditional Chinese medicine.
作者
王羽心
潘鹏宇
赵腾宇
周妍妍
WANG Yuxin;PAN Pengyu;ZHAO Tengyu;ZHOU Yanyan(Heilongjiang University of Traditional Chinese Medicine,Harbin 150040,China;Heilongjiang Province Primary Labo-ratory of Basic Theory Research of Traditional Chinese Medicine,Harbin 150040,China)
出处
《中国病理生理杂志》
北大核心
2025年第8期1633-1638,共6页
Chinese Journal of Pathophysiology
基金
国家自然科学基金资助项目(No.81774197)
黑龙江省自然科学基金资助项目(No.LH2023H057)。
关键词
中药
核苷酸结合寡聚化结构域样受体蛋白3
脑缺血再灌注损伤
炎症
traditional Chinese medicine
nucleotide-binding oligomerization domain-like receptor protein 3
cerebral ischemia-reperfusion injury
inflammation
