摘要
青少年抑郁症的早期识别需要客观的生物学标志。本研究探讨了首发轻中度抑郁症青少年的功能性近红外光谱(fNIRS)脑激活特征及负性失匹配波(mismatch negativity,MMN)变化特点。研究纳入33例首发轻中度抑郁症青少年及33例健康对照者,通过fNIRS检测言语流畅性任务中额叶皮层氧合血红蛋白(Oxy-Hb)浓度变化,并利用事件相关电位(ERP)记录Fz、Cz电极点的MMN潜伏期与波幅。结果显示,抑郁组MMN潜伏期显著延长[Fz:(227.88±31.08)ms vs.(208.70±25.35)ms,P<0.01;Cz:(223.73±29.03)ms vs.(204.18±22.43)ms,P<0.01],Fz点MMN波幅显著降低[(2.42±2.18)μV vs.(5.65±5.59)μV,P=0.03],Fz点MMN潜伏期与Cz点MMN潜伏期呈正相关(P<0.01),且左侧额极前额叶皮层(CH15、CH17)Oxy-Hb浓度低于对照组(P<0.05)。我们的研究结果提示,青少年抑郁症患者存在左侧前额叶功能减退及自动感知处理障碍,fNIRS与ERP技术或可为其早期诊断提供客观依据。
Early identification of adolescent depression requires objective biomarkers.This study investigated the functional near-infrared spectroscopy(fNIRS)activation patterns and mismatch negativity(MMN)characteristics in adolescents with first-episode mild-to-moderate depression.We enrolled 33 patients and 33 matched healthy controls,measuring oxyhemoglobin(Oxy-Hb)concentration in the frontal cortex during verbal fluency tasks via fNIRS,and recording MMN latency/amplitude at Fz/Cz electrodes using event-related potentials(ERP).Compared with healthy controls,the depression group showed significantly prolonged MMN latency[Fz:(227.88±31.08)ms vs.(208.70±25.35)ms,P<0.01;Cz:(223.73±29.03)ms vs.(204.18±22.43)ms,P<0.01],and obviously reduced Fz amplitude[(2.42±2.18)μV vs.(5.65±5.59)μV,P=0.03].A significant positive correlation was observed between MMN latencies at Fz and Cz electrodes(P<0.01).Oxy-Hb in left frontopolar prefrontal channels(CH15/17)was significantly decreased in patient group(P<0.05).Our findings suggest that adolescents with depression exhibit hypofunction in the left prefrontal cortex and impaired automatic sensory processing.The combined application of fNIRS and ERP techniques may provide an objective basis for early clinical identification.
作者
孙宏毅
张林
李静
李振华
黄佳茜
郑重
邹可
SUN Hongyi;ZHANG Lin;LI Jing;LI Zhenhua;HUANG Jiaxi;ZHENG Zhong;ZOU Ke(Neurobiological Laboratory,West China Hospital of Sichuan University,Chengdu 610041,P.R.China;The Department of Rehabilitation Medicine,First People's Hospital of Jintang County,Chengdu 610499,P.R.China;Neurobiological Laboratory,West China Xiamen Hospital of Sichuan University,Xiamen,Fujian 361000,P.R.China)
出处
《生物医学工程学杂志》
北大核心
2025年第4期701-706,共6页
Journal of Biomedical Engineering
基金
四川省自然科学基金项目(2023NSFSC0125)
国家自然科学基金项目(81873354)。
关键词
青少年
抑郁症
功能性近红外光谱成像
负性失匹配波
事件相关电位
Adolescents
Depression
Functional near-infrared spectroscopy
Mismatch negativity
Event-related potentials
