摘要
Bone defects are a common pathology in bone tissue diseases,and existing therapeutic interventions have significant limitations,highlighting the need for innovative strategies and advanced biomaterials.DNA,traditionally recognized as a prominent genetic material,also possesses exceptional properties as a biological material,making it an ideal nanoscale building block for creating various DNA-based biomaterials,such as DNA framework materials and DNA hydrogels.DNA-based biomaterials offer notable advantages,including structural versatility,biocompatibility,and,crucially,programmability,which position them as promising candidates for bone tissue engineering.This review explores recent advancements in the use of DNA-based biomaterials for bionic mineralization and drug delivery systems,as well as their future potential in this field.
基金
supported by the National Key R&D Program of China(2022YFA1603603,2023YFB3810202 and 2022YFB3808200)
National Natural Science Foundation of China(32271385,22074046 and 22377076)
Basic and Applied Basic Research Foundation of Guangdong Province(2022A1515010887 and 2022A1515011839)
Shanghai Pujiang Program(22PJ1408500,to Huan Zhang).
