摘要
目的对慢性阻塞性肺疾病(COPD)稳定期维持治疗的3种吸入用闭合三联制剂(氟替美维吸入粉雾剂、布地格福吸入气雾剂、倍氯福格吸入气雾剂)进行综合评价,以期为医疗机构药品遴选、合理用药提供参考。方法基于《中国医疗机构药品评价与遴选快速指南(第二版)》,参考药物说明书、临床指南及中国国家知识基础设施(CNKI)、万方数据库、维普中文科技期刊数据库(VIP)、PubMed、Embase、Cochrane Library等数据库相关文献,建立量化指标,从有效性、药学特性、安全性、经济性及其他属性共5个维度对3种吸入用闭合三联制剂进行评价。结果纳入评价的制剂综合评分均在80分以上,其中氟替美维吸入粉雾剂综合评分最高(89.2分),布地格福吸入气雾剂次之(87.6分),倍氯福格吸入气雾剂评分最低(82.9分)。结论3种制剂均表现出较好的临床效果,不同三联制剂在临床治疗中有不同的优势。通过对3种吸入用三联制剂的综合评价,可为医疗机构药品遴选提供参考,也为临床科学合理、安全、个体化用药提供依据。
Objective A comprehensive evaluation of three kinds of closed triple therapy(fluticasone furoate,umeclidinium bromide and vilanterol trifenatate powder for inhalation,budesonide,glycopyrronium bromide and formoterol fumarate inhalation aerosol,beclometasone dipropionate,formoterol fumarate and glycopyrrolate inhalation aerosol)for stable maintenance treatment of chronic obstructive pulmonary disease(COPD)is conducted to provide reference for drug selection and rational clinical use in medical institutions.Methods Based on the Quick Guidelines for Drug Evaluation and Selection in Chinese Medical Institutions(Second Edition),this study collected drug instructions,clinical guidelines,and relevant literature from databases such as China National Knowledge Infrastructure(CNKI),Wanfang Database,VIP Database for Chinese Technical Periodicals(VIP),PubMed,Embase and Cochrane Library.Quantitative indicators were established to evaluate three inhalations that closed triple therapy formulations from five dimensions:effectiveness,pharmacological characteristics,safety,economy,and other attributes.Results The comprehensive scores of the formulations included in the evaluation are all above 80 points,among which the comprehensive score of fluticasone furoate,umeclidinium bromide and vilanterol trifenatate powder for inhalation is the highest at 89.2 points,followed by budesonide,glycopyrronium bromide and formoterol fumarate inhalation aerosol at 87.6 points,and the lowest score of beclometasone dipropionate,formoterol fumarate and glycopyrrolate inhalation aerosol at 82.9 points.Conclusions All three formulations have shown good clinical efficacy,and different triple formulations have different advantages in clinical treatment.Through the comprehensive evaluation of three types of inhalation triple preparations,it can provide a reference for drug selection in medical institutions,and provide a basis for clinical scientific,rational,safe,and personalized medication.
作者
张丽娜
索雨杰
李小红
叶志强
闫桦
ZHANG Lina;SUO Yujie;LI Xiaohong;YE Zhiqiang;YAN Hua(Department of Pharmacy,North China Medical and Health Group Fengfeng General Hospital,Handan 056000,China;Department of Internal Medicine,North China Medical and Health Group Fengfeng General Hospital,Handan 056000,China)
出处
《医药导报》
北大核心
2025年第9期1496-1503,共8页
Herald of Medicine
关键词
吸入制剂
药品评价
慢性阻塞性肺疾病
数字化评分
Inhalation preparation
Drug evaluation
Chronic obstructive pulmonary disease
Digital rating
