摘要
目的:评估全血细胞计数(CBC)衍生炎症指标与广西防城港地区男性勃起功能障碍(ED)风险及严重程度之间的关联,并进一步分析其与年龄的联合效应。方法:基于2011年和2013年广西防城港地区男性健康与体检调查(FAMHES)人群,共纳入1057例受试者。采用多因素logistic回归模型分析对数转换后的炎症指标〔中性粒细胞与淋巴细胞比值(NLR)、单核细胞与淋巴细胞比值(MLR)、系统性免疫炎症指数(SII)、系统性炎症反应指数(SIRI)和全血炎症状态指数(AISI)〕与ED的关系;限制性立方样条(RCS)模型用于评估剂量—反应关系,炎症指标与年龄分层分析用于探讨联合效应。结果:ED患病率为53.7%。在完全调整混杂因素后,4项炎症指标(除了SII)水平均与ED风险呈正相关关系(OR:1.27~1.56,P<0.05)。其中,MLR、SIRI和AISI主要与轻度ED相关,而NLR则主要与中重度ED相关。MLR、SIRI、AISI与ED风险之间均呈线性剂量—反应关系。4项炎症指标水平(除了SII)与年龄存在联合作用。结论:CBC衍生炎症指标与ED风险及严重程度相关,其与年龄存在联合作用。
Objective:To evaluate the association between complete blood count(CBC)-derived inflammatory indices and the risk and severity of erectile dysfunction(ED)among men in the Fangchenggang region of Guangxi,China,and to further explore the joint effects of these indices with age.Methods:A total of 1,057 participants were enrolled from the Fangchenggang Area Male Health and Examination Survey(FAMHES)conducted in 2011 and 2013.Multivariable logistic regression models were used to assess the association between log-transformed inflammatory indices[including neutrophil-to-lymphocyte ratio(NLR),monocyte-tolymphocyte ratio(MLR),systemic immune-inflammation index(SII),systemic inflammation response index(SIRI),and aggregate index of systemic inflammation(AISI)]and ED risk.Restricted cubic spline(RCS)models were applied to evaluate dose-response relationships,and inflammatory indicators combined with stratified analyses by age were performed to examine joint effects.Results:The prevalence of ED was 53.7%.After full adjustment for potential confounders,all inflammatory indices except SII were positively associated with ED risk(OR=1.27-1.56,P<0.05).Specifically,MLR,SIRI,and AISI were mainly associated with mild ED,while NLR was primarily associated with moderate-to-severe ED.MLR,SIRI,and AISI showed linear dose-response relationships with ED risk.There were joint effects between the levels of these four inflammatory indices(except SII)and age.Conclusion:CBC-derived inflammatory indices are associated with the risk and severity of ED,and there is a joint effect with age.
作者
林煜
黄胜珠
陆铮
李家龙
莫曾南
LIN Yu;HUANG Shengzhu;LU Zheng;LI Jialong;MO Zengnan(Institute of Urology and Nephrology,the First Affiliated Hospital of Guangxi Medical University,Guangxi Medical University,Nanning 530021,China;Center for Genomic and Personalized Medicine,Guangxi key Laboratory for Genomic and Personalized Medicine,Guangxi Collaborative Innovation Center for Genomic and Personalized Medicine,Guangxi Medical University,Nanning 530021,China)
出处
《广西医科大学学报》
2025年第4期574-582,共9页
Journal of Guangxi Medical University
基金
国家自然科学基金资助项目(No.82270806)
广西重点研发计划项目(No.桂科AB21196022)
广西科技重大专项(No.桂科AA22096030
No.桂科AA22096032)
广西创新驱动发展专项(No.AA18118016)
广西基因组与个体化医学研究重点实验室资助项目(No.22-35-17)。
关键词
勃起功能障碍
炎症
全血细胞计数
炎症指标
横断面研究
erectile dysfunction
inflammation
complete blood count
inflammatory indices
cross-sectional study
