摘要
慢性创面是由特定原因导致的伤口长期不愈合,目前常用治疗手段如负压封闭引流存在肉芽组织过度生长、患者依从性差和费用较高等问题,新兴的干细胞疗法也存在潜在致瘤风险。因此,如何有效地加速创面愈合仍是当前临床研究的重点方向之一。富血小板血浆来源的细胞外囊泡(PRP-EVs)是由血小板在激活后释放的细胞外囊泡,具有自体来源的特性,安全性更高,临床应用方式也更加便捷。PRP-EVs包裹丰富的脂质、蛋白质和RNA等生物活性分子,在调节创面炎症反应、促进血管新生、增强细胞迁移和增殖方面表现突出,有望成为治疗慢性创面的有效工具。本文对PRP-EVs在慢性创面治疗中的方法、作用机制以及面临的挑战进行综述,为该领域的研究及未来临床应用提供依据和参考。
Chronic wounds,defined as persistent failure to heal due to specific etiological factors,remain a major clinical challenge.Current standard interventions such as negative pressure wound therapy are limited by complications like hypergranulation and poor patient compliance,while emerging stem cell-based therapies carry potential tumorigenic risks.Consequently,identifying strategies to safely and effectively accelerate wound healing continues to be a critical focus in contemporary clinical research.Platelet-rich plasma derived extracellular vesicles(PRP-EVs)are extracellular vesicles released by platelets after activation.They have the characteristics of autologous origin,higher safety,and more mild and convenient clinical application.Studies have shown that PRP-EVs are rich in bioactive molecules such as lipids,proteins and RNA,which have outstanding performance in regulating wound inflammation,promoting angiogenesis,enhancing cell migration and proliferation,and are expected to become an effective tool for the treatment of chronic wounds.This review discusses the methods,mechanisms of action,and challenges associated with the use of PRP-EVs in chronic wound management,providing a foundation for future research and clinical applications in this field.
作者
华山
张弘一
顾嘉伟
钱玉鑫
郭荣
史滢深
王祎龙
江华
Hua Shan;Zhang Hongyi;Gu Jiawei;Qian Yuxin;Guo Rong;Shi Yingshen;Wang Yilong;Jiang Hua(Department of Plastic Surgery,Shanghai East Hospital,School of Medicine,Tongji University,Shanghai 200120,China;State Key Laboratory of Cardiology and Medical Innovation Center,Shanghai East Hospital,School of Medicine,Tongji University,Shanghai 200120,China;the Institute for Biomedical Engineering&Nano Science,School of Medicine,Tongji University,Shanghai 200092,China)
出处
《中华医学美学美容杂志》
2025年第4期337-342,共6页
Chinese Journal of Medical Aesthetics and Cosmetology
基金
国家自然科学基金(32271439,32071395)
同济大学附属东方医院引进人才研究启动基金(DFRC2019008)。
关键词
富血小板血浆
细胞外囊泡
慢性创面
分子机制
Platelet-rich plasma
Extracellular vesicles
Chronic wounds
Molecular mechanisms
