摘要
目的从文献计量学和全球专利的角度对半夏Pinelliae Rhizoma的研究现状与热点进行全面分析,为未来半夏的临床应用和深入研究提供理论指导。方法以半夏为关键词检索中国知网(CNKI)、万方(Wanfang)、维普(VIP)、Web of Science(WOS)4个数据库,将文献导入NoteExpress文献管理软件中进行查重和筛选。利用Excel、CiteSpace、VOSviewer等软件,从发文趋势与国家分布、发文机构、发文作者、关键词等维度对国内外的半夏研究现状与发展趋势进行可视化分析。通过Incopat专利数据库从专利申请趋势、全球地域分布、专利申请人及专利技术领域等方面检索并分析半夏相关全球专利申请情况。结果共检索到符合标准的中文文献2376篇,英文文献741篇。发文国家以中国为主,近些年来国际关注度逐渐升高。半夏领域的核心团队已经初步形成,但机构之间的合作效应尚未充分展现。近年来半夏领域中英文文献研究热点存在重叠,均聚焦于半夏及其方剂、有效成分与作用机制,且广泛运用了网络药理学等系统生物学方法。基于Incopat专利数据库检索得到专利数据16325件,进行同族合并后得到专利13672件,其中国内专利有13337件,占比97.48%,占据了绝对的主导地位。结论半夏领域的研究正不断拓展和深入,整体来看,研究正从传统中医药应用向多学科交叉、分子机制深度解析方向拓展。我国半夏专利申请量在全球专利申请格局中占据绝对主导地位,但当前仍面临专利失效数量较多、成果转化程度偏低、市场竞争力不强等现实问题。
Objective To comprehensive analyze the research status and hotspots of Banxia(Pinelliae Rhizoma)from the perspectives of bibliometrics and global patents,and to provide theoretical guidance for the future clinical application and in-depth research of Pinelliae Rhizoma.Methods The keyword“Pinelliae Rhizoma”was used to search four databases:China National Knowledge Infrastructure(CNKI),Wanfang,VIP,and Web of Science(WOS).The literature was imported into NoteExpress literature management software for duplicate checking and screening.Software such as Excel,CiteSpace,and VOSviewer were used to conduct visualization analysis of domestic and foreign research on Pinelliae Rhizoma from dimensions including publication trends and national distribution,In recent years,research hotspots in Chinese and English literature in the field of Pinelliae Rhizoma have overlapped,focusing on Pinelliae Rhizoma and its formulas,active ingredients and action mechanisms,and widely using systems biology methods such as network pharmacology.Based on the Incopat patent database,16325 patent data were retrieved,and after family consolidation,13672 patents were obtained,among which 13337 were domestic patents,accounting for 97.48%,occupying an absolute dominant position.Conclusion The research in the field of Pinelliae Rhizoma is continuously expanding and deepening.Overall,the research is expanding from traditional Chinese medicine applications to multidisciplinary intersections and in-depth analysis of molecular mechanisms.China occupies an absolute dominant position in the global patent applications for Pinelliae Rhizoma,but it still faces problems such as a large number of invalid patents,low transformation efficiency,and weak market competitiveness.
作者
商素菲
王进
SHANG Sufei;WANG Jin(Institute of Chinese Medical Literature,Nanjing University of Chinese Medicine,Nanjing 210023,China;Jiangsu Provincial Research Institute of Chinese Medicine Schools,Nanjing 210023,China)
出处
《中草药》
北大核心
2025年第14期5151-5168,共18页
Chinese Traditional and Herbal Drugs
基金
国家自然科学基金项目(81904322)
国家中医药管理局高水平中医药重点学科建设项目(ZYYZDXK-2023073)
江苏省中医药管理局专题项目(JSZYLP2024044)。
