摘要
本研究系统阐述吲哚菁绿(ICG)荧光成像技术在感染性胆囊炎手术中的应用及病原学关联机制。ICG通过“血液-肝细胞屏障主动摄取-肝细胞-胆小管屏障定向排泄-胆道-胆囊屏障渗漏调控”三重代谢通路实现肝胆特异性显影,感染通过下调转运蛋白、竞争排泄通道及破坏黏膜屏障改变其时空分布。定量荧光成像技术构建了三维评估体系,术前可通过FIT值和ICG-PDR精准分期,术中结合荧光导航实现解剖变异识别、感染灶边界界定及病原快速检测。ICG荧光成像可从分子机制、病原分型到临床决策形成闭环,为感染性胆囊炎的精准诊疗提供新范式。
This study systematically elaborates on the application of indocyanine green(ICG)fluorescence imaging technology in the surgery of infectious cholecystitis and its association mechanism with etiology.ICG achieves specific hepatobiliary imaging through a triple metabolic pathway of"active uptake by the blood-hepatocyte barrier,directional excretion by the hepatocyte-bile ductule barrier,and leakage regulation of the biliary-gallbladder barrier".Infection alters its spatiotemporal distribution by down-regulating transporters,competing for excretion channels,and disrupting the mucosal barrier.Quantitative fluorescence imaging technology has constructed a three-dimensional evaluation system.Pre-operatively,accurate staging can be achieved through the FIT value and ICG-PDR.Intra-operatively,combined with fluorescence navigation,anatomical variations can be identified,the boundaries of infectious foci can be defined,and rapid pathogen detection can be realized.ICG fluorescence imaging can form a closed-loop from molecular mechanisms,pathogen typing to clinical decision-making,providing a new paradigm for the precise diagnosis and treatment of infectious cholecystitis.
作者
金涛
王荇
史凯航
王晓冬
张楷
JIN Tao;WANG Xing;SHI Kaihang;WANG Xiaodong;ZHANG Kai(Yiring Hospital Affiliatedto Jiangsu University,Yiring,Jiangshu 214200,China)
出处
《中国病原生物学杂志》
北大核心
2025年第10期1378-1382,共5页
Journal of Pathogen Biology
关键词
吲哚菁绿
荧光成像
感染性胆囊炎
病原学
精准诊疗
综述
indocyanine green
fluorescence i imaging
infectious cholecystitis
etiology
precise diagnosis and treatment
reivew
