摘要
目的探究不同压力高压氧(HBO)治疗缺氧缺血性脑病(HIE)患儿对其红细胞压积(HCT)、血小板计数(PLT)、平均血小板体积(MPV)的影响。方法选取山西省儿童医院2016年1月至2019年12月收治的120例HIE患儿为研究对象,按照随机数字表法将患儿分为对照组(n=41)、治疗1组(n=39)、治疗2组(n=40)。对照组患儿给予常规治疗,治疗1组、治疗2组患儿在对照组治疗基础上分别给予0.20 MPa(2.00 ATA)、0.25 MPa的HBO治疗,均连续治疗2周。比较3组患儿的临床疗效、肌张力恢复时间、意识恢复时间、反射恢复时间,以及治疗前后HCT、PLT、MPV差异。结果治疗1组、治疗2组患儿临床有效率(74.36%、92.50%)均明显高于对照组(41.46%),且治疗2组明显高于治疗1组,差异均有统计学意义(均P<0.05);治疗1组、治疗2组患儿的肌张力恢复时间[(4.01±0.58)d、(3.68±0.62)d]、意识恢复时间[(3.39±0.49)d、(3.01±0.52)d]、反射恢复时间[(4.58±0.69)d、(4.03±0.65)d]均明显短于对照组[(4.52±0.65)d、(3.88±0.56)d、(5.02±0.75)d],且治疗2组上述指标均明显短于治疗1组,差异均有统计学意义(均P<0.05)。治疗后3组患儿PLT水平均较治疗前明显升高,HCT、MPV水平均较治疗前明显下降;治疗1组、治疗2组患儿治疗后上述指标改善均明显优于对照组,且治疗2组明显优于治疗1组[(255.17±26.03)×10^(9)/L比(245.69±25.01)×10^(9)/L、(40.28±4.19)%比(41.02±5.21)%、(8.42±0.85)fl比(9.35±0.96)fl],差异均有统计学意义(均P<0.05)。结论HBO治疗HIE患儿可明显改善其HCT、PLT、MPV水平,且0.25 MPa HBO治疗的临床疗效优于0.20 MPa HBO治疗。
Objective:To investigate the effects of hyperbaric oxygen(HBO)therapy at different pressures on hematocrit(HCT),platelet count(PLT),and mean platelet volume(MPV)in children with hypoxic-ischemic encephalopathy(HIE).Methods:A total of 120 children with HIE admitted to Shanxi Children's Hospital from January 2016 to December 2019 were prospectively selected as the study subjects.According to the random number table method,the children were divided into a control group(n=41),treatment group 1(n=39),and treatment group 2(n=40).The control group received conventional treatment,while the treatment group 1 and the treatment group 2,in addition to the conventional treatment,received HBO therapy at 0.20 MPa(2.0 ATA)and 0.25 MPa,respectively.All treatments lasted for two weeks.The clinical efficacy,muscle tone recovery time,consciousness recovery time,reflex recovery time,and levels of HCT,PLT,and MPV before and after treatment were compared among the three groups.Results:The clinical effective rates in treatment group 1 and treatment group 2(74.36%,92.50%,respectively)were significantly higher than that in the control group(41.46%),and the rate in treatment group 2 was significantly higher than that in treatment group 1,with statistically significant differences(all P<0.05).The muscle tone recovery time[(4.01±0.58)d,(3.68±0.62)d],consciousness recovery time[(3.39±0.49)d,(3.01±0.52)d],and reflex recovery time[(4.58±0.69)d,(4.03±0.65)d]in treatment group 1 and treatment group 2 were significantly shorter than those in the control group[(4.52±0.65)d,(3.88±0.56)d,(5.02±0.75)d],and the above indicators in treatment group 2 were significantly shorter than those in treatment group 1,with statistically significant differences(all P<0.05).After treatment,PLT levels in all three groups significantly increased,while HCT and MPV levels significantly decreased.The improvements in these indicators were more pronounced in treatment groups 1 and 2 compared with the control group,with treatment group 2 showing better results than treatment group 1[PLT:(255.17±26.03)×10^(9)/L vs.(245.69±25.01)×10^(9)/L;HCT:(40.28±4.19)%vs.(41.02±5.21)%;MPV:(8.42±0.85)fl vs.(9.35±0.96)fl](all P<0.05).Conclusion:HBO therapy can significantly improve HCT,PLT,and MPV levels in children with HIE,and the clinical efficacy of 0.25 MPa HBO therapy is superior to that of 0.20 MPa HBO therapy.
作者
张志红
王五桃
张鲜惠
张丽荣
Zhang Zhihong;Wang Wutao;Zhang Xianhui;Zhang Lirong(Clinical Laboratory Center,Shanxi Children's Hospital,Taiyuan 030000,China;Department of Internal Medicine,Shanxi Children's Hospital,Taiyuan 030000,China;Hyperbaric Oxygen Therapy Center,Shanxi Children's Hospital,Taiyuan 030013,China)
出处
《中华航海医学与高气压医学杂志》
2025年第7期731-735,共5页
Chinese Journal of Nautical Medicine and Hyperbaric Medicine
