摘要
目的探讨通过定量CT(QCT)测量不同年龄段腰椎体积骨密度(vBMD)、椎旁肌脂肪含量以及骨质疏松患病率的差异,并分析腰椎vBMD与椎旁肌(包括腰大肌、多裂肌、竖脊肌)脂肪含量之间的相关性。方法本研究纳入742例于2022年12月至2023年12月在我院接受腰椎CT检查的个体。根据年龄分组为中青年组(≤60岁)和老年组(>60岁),并按照腰椎vBMD分为骨量正常、骨量减低和骨质疏松组,比较各组间的年龄及椎旁肌脂肪含量差异。采用Spearman相关分析以及偏相关与多元线性回归分析评估腰椎vBMD与椎旁肌脂肪含量、年龄、性别之间的关系。结果老年组的腰椎vBMD显著低于中青年组,而椎旁肌脂肪含量和骨质疏松患病率显著高于中青年组,差异均具有统计学意义(P<0.001)。年龄与腰大肌、多裂肌及竖脊肌脂肪含量在骨量正常组中最低,在骨质疏松组中最高,三组间差异有统计学意义(P<0.001)。Spearman相关分析显示,腰椎vBMD与年龄、腰大肌脂肪含量、多裂肌脂肪含量及竖脊肌脂肪含量均呈负相关(r=-0.627、-0.173、-0.396、-0.278,P<0.001);在控制年龄及性别因素后,腰椎vBMD与多裂肌脂肪含量呈负相关(r=-0.091,P=0.014),与腰大肌及竖脊肌脂肪含量无显著相关性(P>0.05)。多元线性回归分析显示,多裂肌脂肪含量、年龄及性别是腰椎vBM D的独立影响因素。结论老年组腰椎vBMD显著低于中青年组,且椎旁肌脂肪含量和骨质疏松患病率显著高于中青年组。此外,腰椎vBMD与多裂肌脂肪含量呈负相关。
Objective This study aims to investigate the differences in lumbar volumetric bone mineral density(vBMD),paravertebral muscle fat content,and the prevalence of osteoporosis among different age groups measured by quantitative CT(QCT).Additionally,it aims to analyze the correlation between lumbar vBMD and paravertebral muscle fat content,including psoas major,multifidus,and erector spinae muscles.Methods A total of 742 individuals who underwent CT examination of the lumbar spine at our hospital from December 2022 to December 2023 were included in this study.Based on age groups,participants were divided into a young and middle-aged group(≤60 years old)and an old group(>60 years old).The lumbar vBMD was used to classify individuals into normal bone mass,low bone mass,or osteoporosis groups.Differences in age and paravertebral muscle fat content were compared among these groups.Spearman correlation analysis along with partial correlation and multiple linear regression analysis were conducted to evaluate the relationship between lumbar vBMD and paravertebral muscle fat content as well as other factors such as age and sex.Results The lumbar volumetric bone mineral density(vBMD)of the elderly group was significantly lower than that of the young and middle-aged groups,while the paravertebral muscle fat content and prevalence of osteoporosis were significantly higher compared to the young and middle-aged groups,with statistical significance(P<0.001).The age and fat content in psoas major,multifidus,and erector spinalis muscles were found to be lowest in the normal bone mass group but highest in the osteoporosis group,with statistical significance(P<0.001).Spearman correlation analysis revealed a negative correlation between lumbar vBMD and age,psoas major fat content,multifidus fat content,as well as vertical spinal fat content(r=-0.627,-0.173,-0.396,-0.278,P<0.001).After controlling for age and sex variables,lumbar vBMD showed a negative correlation only with multifidus fat content(r=-0.091,P=0.014),while no significant correlations were observed with psoas or erector spinalis fat content(P>0.05).Multiple linear regression analysis demonstrated that multifidus muscle's fat content along with age and sex were independent influencing factors on lumbar vBMD.Conclusion The lumbar vBMD of elderly individuals was significantly lower compared to both middle-aged and young individuals'groups;moreover,the paravertebral muscle's fat content as well as prevalence of osteoporosis were also significantly higher among elderly individuals when compared to middleaged and young individuals'groups.Additionally,lumbar vBMD exhibited a negative correlation with multifidus'fatcontent.
作者
李建隆
王中秋
谢玉海
魏天贤
张宁宁
夏鹏
LI Jian-long;WANG Zhong-qiu;XIE Yu-hai;WEI Tian-xian;ZHANG Ning-ning;XIA Peng(Department of Radiology,Taihe County People’s Hospital,Taihe 236600,Anhui Province,China;Department of Radiology,Affiliated Hospital of Nanjing University of Chinese Medicine,Nanjing 210000,Jiangsu Province,China;Department of Radiology,Wuxi Hospital of Traditional Chinese Medicine,Wuxi 214071,Jiangsu Province,China)
出处
《中国CT和MRI杂志》
2025年第8期175-178,共4页
Chinese Journal of CT and MRI
基金
安徽省高校科学研究重点项目(2024AH051914)。
关键词
骨密度
椎旁肌
脂肪含量
定量CT
Bone Mineral Density
Paravertebral Muscle
Fat Content
Quantitative Computed Tomography
