摘要
目的探究动态增强磁共振成像(DCE-MRI)定量参数[血管外细胞外间隙容积比(Ve)、速率常数(K_(ep))、容量转移常数(K^(trans))]、血清胰岛素样生长因子-1(ICF-1)水平联合检测对子宫肌瘤患者治疗效果的评估价值。方法收集90例2022年3月至2024年1月于我院就诊的子宫肌瘤患者(均行子宫肌瘤剔除术)为研究组,另选取同期90例体检健康者为对照组,比较两组DCE-MRI定量参数、血清ICF-1水平,根据术后3个月复发情况比较不同疗效患者DCE-MRI定量参数、血清ICF-1水平,采用Spearman法、受试者工作特性(ROC)曲线分析相关性、评估价值。结果研究组K_(ep)、K^(trans)、Ve值及血清IC F-1水平均高于对照组,差异存在统计学意义(P<0.05);治疗有效者K_(ep)、K^(trans)、Ve值及血清ICF-1水平均明显低于治疗无效者,差异存在统计学意义(P<0.05);K_(ep)、K^(trans)、Ve值及血清ICF-1水平均与治疗效果呈正相关(P<0.05);K_(ep)、K^(trans)、Ve值及血清ICF-1水平联合评估子宫肌瘤患者治疗无效的AUC为0.862,最佳预测敏感度为94.12%,特异度为78.18%。结论DCEMRI定量参数联合血清IC F-1水平对子宫肌瘤治疗效果具有一定评估价值,可作为临床评估子宫肌瘤患者治疗效果的辅助指标。
Objective To explore the value of combined detection of dynamic contrast-enhanced magnetic resonance imaging(DCE-MRI)quantitative parameters[extracellular space volume ratio(Ve),rate constant(K_(ep)),and volume transfer constant(K^(trans))]and serum insulin-like growth factor-1(ICF-1)levels in evaluating the therapeutic effect on patients with uterine fibroids.Methods A total of 90 patients with uterine fibroids who underwent myomectomy in our hospital from March 2022 to January 2024 were selected as the study group,and another 90 healthy individuals undergoing physical examination during the same period were selected as the control group.The quantitative parameters of DCE-MRI and serum ICF-1 levels were compared between the two groups.According to the recurrence status three months after surgery,the quantitative parameters of DCE-MRI and serum ICF-1 levels were compared among patients with different therapeutic effects.Spearman's correlation analysis and receiver operating characteristic(ROC)curve analysis were used to evaluate the correlation and value of the results.Results The values of K_(ep),K^(trans),Ve and serum ICF-1 levels in the study group were higher than those in the control group,and the difference was statistically significant(P<0.05).The values of K_(ep),K^(trans),Ve and serum ICF-1 levels in patients with effective treatment were significantly lower than those in patients with ineffective treatment,and the difference was statistically significant(P<0.05).The values of K_(ep),K^(trans),Ve and serum ICF-1 levels were positively correlated with the therapeutic effect(P<0.05).The AUC of the combined assessment of K_(ep),K^(trans),Ve values and serum ICF-1 level for ineffective treatment in patients with uterine leiomyoma was 0.862,with an optimal predictive sensitivity of 94.12%and a specificity of 78.18%.Conclusion The quantitative parameters of DCE-MRI combined with serum ICF-1 levels have certain evaluation value for the therapeutic effect of uterine fibroids,and can be used as an auxiliary indicator for clinical evaluation of the therapeutic effect in patients with uterine leiomyoma.
作者
王玉凤
续晓楠
华冰
魏雯雯
Wang Yu-feng;Xu Xiao-nan;Hua Bing;Wei Wen-wen(Department of Gynecology,The Second Children&Women's Healthcare of Jinan,Jinan 271100,Shandong Province,China;Department of Imaging,Jinan City People's Hospital,Jinan 271100,Shandong Province,China)
出处
《中国CT和MRI杂志》
2025年第8期133-135,共3页
Chinese Journal of CT and MRI
基金
山东省医药卫生科技发展计划项目(202105010536)。
关键词
子宫肌瘤
治疗效果
动态增强磁共振成像
胰岛素样生长因子-1
Uterine Fibroids
Therapeutic Effect
Dynamic Contrast-enhanced Magnetic Resonance Imaging
Insulin-like Growth Factor 1
