摘要
目的探究双气相CT参数对慢性阻塞性肺病(COPD)严重程度的评估价值分析。方法选取2020年12月到2024年9月收治的145例COPD患者。根据慢阻肺全球倡议中的分级标准(GOLD),将患者分为低风险组(n=87,GOLD1~2级)与高风险组(n=58,GOLD3~4级)。统计2组基线资料与临床指标,对比2组双气相CT参数,采用二元Logistic方程分析双气相CT参数与病情严重程度相关性,采用ROC曲线分析双气相CT参数对高风险COPD的预测价值。结果高风险组病程、吸烟史、NLR、hs-CRP显著高于低风险组(P<0.05),FEV1、FVC显著低于低风险组(P<0.05);高风险组LV_(in)、LV_(ex)、El、AT显著高于低风险组(P<0.05),而MLD_(in)、MLD_(ex)显著低于低风险组(P<0.05);LV_(in)、LV_(ex)、MLD_(in)、MLD_(ex)、EI、AT均与患COPD严重程度相关(P<0.05);LV_(in)、LV_(ex)、MLD_(in)、MLD_(ex)、EI、AT预测患者COPD严重程度的AU C分别为0.699、0.880、0.796、0.738、0.891、0.779;6项联合诊断患者严重程度的AUC、敏感度、特异度分别为0.990、89.47%及60.92%,联合诊断价值更高。结论双气相CT可有效评估COPD疾病进展情况,其中LV_(in)、LV_(ex)、EI、AT异常升高,MLD_(in)、MLD_(ex)异常降低提示患者疾病进展加重。
Objective To explore the evaluation value of dual meteorological CT parameters for the severity of chronic obstructive pulmonary disease(COPD).Methods 145 patients with COPD admitted from December 2020 to September 2024 were enrolled.According to the Global Initiative for Chronic Obstructive Pulmonary Disease(GOLD)classification criteria,the patients were divided into low-risk group(n=87,GOLD grade 1-2)and high-risk group(n=58,GOLD grade 3-4).The baseline data and clinical indicators of the two groups were statistically analyzed,and the biphasic CT parameters were compared.The correlation between biphasic CT parameters and disease severity was analyzed by binary logistic equation.ROC curve was used to analyze the predictive value of biphasic CT parameters on high-risk COPD.Results The course of disease,smoking history,NLR and hs-CRP in high-risk group were significantly higher than those in lowrisk group(P<0.05)while the FEV1 and FVC were significantly lower than those in low-risk group(P<0.05).LV_(in),LV_(ex),EI and AT in high-risk group were significantly higher(P<0.05)while MLD_(in) and MLD_(ex) were significantly lower compared with those in low-risk group(P<0.05).LV_(in),LV_(ex),MLD_(in),MLD_(ex),EI and AT were correlated with the severity of COPD(P<0.05).The AUCs of LV_(in),LV_(ex),MLD_(in),MLD_(ex),EI and AT in predicting the severity of COPD were 0.699,0.880,0.796,0.738,0.891 and 0.779 respectively.The AUC,sensitivity and specificity of the combination of six indicators in the diagnosis of severity of patients were 0.990,89.47%and 60.92%,and the combined diagnostic value was higher.Conclusion Biphasic CT related parameters can effectively evaluate the progress of COPD patients.The abnormal increases of LV_(in),LV_(ex),EI and AT and the abnormal decreases of MLD_(in) and MLD_(ex) indicate the aggravation of disease progression.
作者
郝显华
刘永华
马国强
校延鑫
黄伟鹏
李伟
HAO Xian-hua;LIU Yong-hua;MA Guo-qiang;XIAO Yan-xin;HUANG Wei-peng;LI Wei(Department of Radiological Diagnosis,Baoji High-tech Hospital,Baoji 721000,Shaanxi Province,China)
出处
《中国CT和MRI杂志》
2025年第8期48-51,共4页
Chinese Journal of CT and MRI
基金
2023年省级继续医学教育项目备案项目(2023-03-02-025)。
关键词
慢性阻塞性肺病
双气相CT
肺功能
预测价值
Chronic Obstructive Pulmonary Disease
Biphasic CT
Lung Function
Predictive Value
