摘要
目的探究自贡地区成年体检人群隐匿性HBV感染现状及血清学特征。方法筛选2023年4月至2024年9月于自贡市第一人民医院体检中心和消化内科进行检查的126381例患者,将符合条件的21615例纳入研究。分析感染现状,比较纳入者血清学模式、血清特征。结果研究筛选患者126381例,全部患者接受血清HBsAg检查,21615例(17.10%)接受HBV DNA检查,其中7992例为HBV DNA阳性(>102 IU/mL)且HBsAg阴性,占接受HBV DNA检查人数的36.97%。抗-HBc阳性率明显高于其他血清学模式,抗-HBc、抗-HBs和抗-HBe均阳性者HBV DNA阳性率最低。抗-HBc、抗-HBs、抗-HBe均阳性患者中男女比例最低(1.25∶1),明显低于其他三种血清学特征患者(P=0.005)。不同血清特征患者年龄、BMI、AST、ALT和TBiL水平无明显差异(均P>0.05)。抗-HBc合并抗-HBe阳性患者HBV病毒载量最高,抗-HBc阳性、抗-HBs阳性、抗-HBe均阳性患者HBV病毒载量最低(P<0.001)。病毒基因型以B型为主,四组患者基因型分布存在差异(P<0.001)。结论自贡地区成年体检人群隐匿性HBV感染水平较高,多表现为抗-HBc阳性,抗-HBc、抗-HBs、抗-HBe均阳性患者中男女比例最低,抗-HBc合并抗-HBe阳性患者HBV病毒载量最高。
Objective To investigate the current status and serologic characteristics of occult HBV infection in the adult physical examination population in Zigong region.Methods A total of 126381 patients who were examined in the physical examination center and gastroenterology department of The First People′s Hospital of Zigong City from April 2023 to September 2024 were screened,and 21615 eligible cases were included in the study.The current status of infection was analyzed and serological patterns and serological characteristics of the included individuals were compared.Results This study screened 126381 patients,all of whom underwent serum HBsAg testing,and 21615 patients(17.10%)underwent HBV DNA testing,of which 7992 were HBV DNA positive(>102 IU/mL)and HBsAg negative,accounting for 36.97%of the total number of patients who underwent HBV DNA testing.Anti-HBc positivity was significantly higher than other serologic patterns,and the lowest rate of HBV DNA positivity was found in those who were positive for anti-HBc,anti-HBs and anti-HBe.The lowest male-to-female ratio(1.25∶1)was found in patients with both anti-HBc,anti-HBs and anti-HBe positivity,which was significantly lower than that of patients with the other three serologic characteristics(P=0.005).There were no significant differences in age,BMI,AST,ALT,and TBiL levels among patients with different serum characteristics(all P>0.05).The HBV viral load is highest in patients with anti HBc combined with anti HBe positivity,while the HBV viral load is lowest in patients with anti HBc positivity,anti HBs positivity,and all anti HBe positivity(P<0.001).Viral genotypes were predominantly B-type,and there were differences in genotype distribution among the four groups of patients(P<0.001).Conclusion The level of occult HBV infection was high in the adult medical examination population in Zigong region,mostly characterized by anti-HBc positivity,with the lowest male-to-female ratio among patients who were positive for anti-HBc,anti-HBs,and anti-HBe,and the highest HBV viral load among patients who were positive for anti-HBc combined with anti-HBe.
作者
邹燕
李智
王兰
钟黄
ZOU Yan;LI Zhi;WANG Lan;ZHONG Huang(Department of Gastroenterology,First People′s Hospital of Zigong City,Zigong,Sichuan 643000,China)
出处
《公共卫生与预防医学》
2025年第5期130-133,共4页
Journal of Public Health and Preventive Medicine
基金
四川大学自贡市校地科技合作专项(2022CDZG-26)。
