摘要
目的:分析子宫内膜癌患者血清糖类抗原125(CA125)和人附睾蛋白4(HE4)水平变化及其在评估患者淋巴结转移中的临床意义。方法:收集2022年1月-2024年1月本院诊疗的子宫内膜癌患者104例临床资料,分为转移组(n=21)及未转移组(n=83),分析不同临床资料和病理特征患者血清CA125、HE4水平差异,明确子宫内膜癌患者淋巴结转移的风险性因素,Spearman相关系数分析CA125及HE4水平与淋巴结转移的关系,并分析两者在患者淋巴结转移中的预测价值。结果:转移组年龄≥60岁、肌层浸润深度≥1/2、病灶范围为弥漫型占比和血清CA125、HE4水平均高于未转移组(均P<0.05)。多因素logistic回归分析显示,肌层浸润深度≥1/2、病灶范围为弥漫型和血清CA125升高、HE4升高是子宫内膜癌患者淋巴结转移的独立影响因素(P<0.05)。Spearman相关系数显示子宫内膜癌患者血清CA125、HE4水平与淋巴结转移呈正相关(P<0.05)。血清CA125联合HE4预测患者淋巴结转移的曲线下面积为0.860、特异度88.5%。结论:血清CA125与HE4水平与患者淋巴结转移紧密相关,两项联合检测可提高子宫内膜癌患者淋巴结转移的预测价值。
Objective:To analyze the changes of the serum carbohydrate antigen(CA125)and human epididymis protein 4(HE4)levels of patients with endometrial cancer,and to evaluate their clinical significances for evaluating the lymph node metastasis of the patients.Methods:The clinical data of 104 patients with endometrial cancer diagnosed and treated in the hospitals from January 2022 to January 2024 were collected.These patients were divided into two groups,including 21 patients with metastasis in group A and 83 patients without metastasis in group B.The differences of the serum CA125 and HE4 levels among the patients with endometrial cancer and with different clinical data and pathological characteristics were analyzed to identify the risk factors of the lymph node metastasis of the patients.Spearman correlation coefficient analysis was conducted to discuss the correlation between the CA125 and HE4 levels of the patients with endometrial cancer and their lymph node metastasis.The predictive values of the CA125 and HE4 levels of the patients with endometrial cancer for their lymph node metastasis were analyzed.Results:The proportions of the patients with age≥60 years old,the depth of the myometrial invasion≥1/2,the diffuse type lesions,and the levels of serum CA125 and HE4 of the patients in group A were significantly higher than those of the patients in group B(all P<0.05).Multivariate logistic regression analysis showed that the depth of myometrial invasion≥1/2,the diffuse type lesions,the elevated serum CA125 and HE4 levels of the patients with endometrial cancer were the independent factors influencing their lymph node metastasis(P<0.05).Spearman correlation coefficient showed that the serum CA125 and HE4 levels of the patients with endometrial cancer were positively correlated with their lymph node metastasis(P<0.05).The area under the curve and the specificity of the serum CA125 level combined with the HE4 level of the patients with endometrial cancer for predicting their lymph node metastasis were 0.860 and 88.5%.Conclusion:The serum CA125 and HE4 levels of the patients with endometrial cancer are closely related to their lymph node metastasis.The combination of the serum CA125 and HE4 levels of the patients with endometrial cancer for predicting their lymph node metastasis can improve the value.
作者
郭盛
尚云
牛丽娜
魏斌
GUO Sheng;SHANG Yun;NIU Lina;WEI Bin(Yuncheng Central Hospital,Shanxi Medical University,Yuncheng,Shanxi Province,044300)
出处
《中国计划生育学杂志》
2025年第8期1885-1889,共5页
Chinese Journal of Family Planning
关键词
子宫内膜癌
淋巴结转移
糖类抗原125
人附睾蛋白4
相关性
预测
Endometrial cancer
Lymph node metastasis
Carbohydrate antigen 125
Human epididymis protein 4
Correlation
Prediction
