摘要
目的:观察经鼻间歇正压通气联合枸橼酸咖啡因治疗早产儿呼吸暂停患儿的效果。方法:选取2022—2023年该院收治的113例呼吸暂停早产儿进行前瞻性研究,根据随机数字表法将其分为对照组56例和观察组57例。两组均给予常规对症处理,在此基础上,对照组给予枸橼酸咖啡因治疗,观察组在对照组基础上联合经鼻间歇正压通气治疗,比较两组临床疗效,临床相关指标(住院时间、呼吸机使用时间、氧疗时间、呼吸暂停消失时间)水平,治疗前后血气分析指标[动脉血氧分压(PaO_(2))、动脉血二氧化碳分压(PaCO_(2))、pH值]、肺功能指标(潮气量、潮气呼气峰流量、每分通气量、达峰容积比、达峰时间比)水平,以及不良反应发生率。结果:观察组治疗总有效率为94.74%(54/57),高于对照组的76.79%(43/56),差异有统计学意义(P<0.05);观察组住院时间、呼吸机使用时间、氧疗时间、呼吸暂停消失时间均短于对照组,差异有统计学意义(P<0.05);治疗后,观察组PaO_(2)水平、pH值均高于对照组,PaCO_(2)水平低于对照组,差异有统计学意义(P<0.05);治疗后,观察组潮气量、潮气呼气峰流量、每分通气量、达峰容积比、达峰时间比均高于对照组,差异有统计学意义(P<0.05);两组不良反应发生率比较,差异无统计学意义(P>0.05)。结论:经鼻间歇正压通气联合枸橼酸咖啡因治疗早产儿呼吸暂停患儿可提高治疗总有效率和肺功能指标水平,改善血气分析指标和临床相关指标水平,效果优于单纯枸橼酸咖啡因治疗。
Objective:To observe effects of nasal intermittent positive pressure ventilation combined with Caffeine citrate in treatment of premature infants with apnea.Methods:A prospective study was conducted on 113 premature infants with apnea admitted to this hospital from 2022 to 2023.According to the random number table method,they were divided into control group(56 cases)and observation group(57 cases).Both groups were given routine symptomatic treatment.On this basis,the control group was treated with Caffeine citrate,while the observation group was treated with nasal intermittent positive pressure ventilation on the basis of that of the control group.The clinical efficacy,the levels of clinical related indexes(hospitalization time,ventilator use time,oxygen therapy time,apnea disappearance time),blood gas analysis indexes[arterial partial pressure of oxygen(PaO_(2)),arterial partial pressure of carbon dioxide(PaCO_(2)),pH value]and lung function indexes(tidal volume,volume at peak tidal expiratory flow,minute ventilation volume,ratio of volume at peak tidal expiratory flow to expiratory tidal volume,ratio of time to peak tidal expiratory flow to total expiratory time)before and after the treatment,and the incidence of adverse reactions were compared between the two groups.Results:The total effective rate of the observation group was 94.74%(54/57),which was higher than 76.79%(43/56)of the control group,and the difference was statistically significant(P<0.05).The hospitalization time,the ventilator use time,the oxygen therapy time and the apnea disappearance time in the observation group were shorter than those in the control group,and the differences were statistically significant(P<0.05).After the treatment,the PaO_(2)level and the pH value of the observation group were higher than those of the control group,the PaCO_(2)level was lower than that of the control group,and the differences were statistically significant(P<0.05).After the treatment,the levels of tidal volume,volume at peak tidal expiratory flow,minute ventilation volume,ratio of volume at peak tidal expiratory flow to expiratory tidal volume,ratio of time to peak tidal expiratory flow to total expiratory time of the observation group were higher than those of the control group,and the differences were statistically significant(P<0.05).However,there was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusions:Nasal intermittent positive pressure ventilation combined with Caffeine citrate in the treatment of the premature infants with apnea can improve the total effective rate of treatment and the levels of lung function indexes,and improve the levels of blood gas analysis indexes and clinical related indexes.Moreover,it is superior to simple Caffeine citrate treatment.
作者
邹晴
方玉玲
彭晓瑞
谢双霞
胡艳松
ZOU Qing;FANG Yuling;PENG Xiaorui;XIE Shuangxia;HU Yansong(Department of Neonatology of Xuchang Maternal and Child Health Hospital,Xuchang 461000 Henan,China)
出处
《中国民康医学》
2025年第16期67-69,83,共4页
Medical Journal of Chinese People’s Health
关键词
早产儿呼吸暂停
经鼻间歇正压通气
枸橼酸咖啡因
肺功能
血气分析
不良反应
Premature infants with apnea
Nasal intermittent positive pressure ventilation
Caffeine citrate
Lung function
Blood gas analysis
Adverse reaction
