摘要
噻虫嗪属于第二代新烟碱类杀虫剂, 主要作用于烟碱型乙酰胆碱受体(nAChR), 严重中毒患者可致呼吸衰竭、休克, 甚至死亡。噻虫嗪中毒报道较少, 其并发横纹肌溶解患者更为少见。本文回顾了1例口服噻虫嗪中毒的治疗经过。该患者服药后即出现轻度横纹肌溶解(肌酸激酶:1 581 U/l)及肾功能损害(肌酐:127 μmol/L), 第2天达到高峰(肌酸激酶:16 329 U/l)。后经临床积极治疗(血液净化、导泻、胃肠减压及脏器支持等), 患者横纹肌溶解症状逐渐好转, 病情平稳后出院。提示救治噻虫嗪中毒时, 应警惕横纹肌溶解症的发生。
Thiamethoxam belongs to the second-generation neonicotinoid insecticides,mainly acting on nicotinic acetylcholine receptors(nAChR).Severe poisoning cases can lead to respiratory failure,shock,and even death.There are relatively few reports on thiamethoxam poisoning,and few literature reports on concurrent rhabdomyolysis cases have been found so far.This article reviews the treatment process of a case of oral thiamethoxam poisoning.The patient developed mild rhabdomyolysis(CK:1581 U/l)and renal dysfunction(creatinine:127μmol/L)immediately after taking the medication,reaching its peak on the second day(CK:16329 U/l).After active treatment(such as Blood purification,drainage,gastrointestinal decompression and organ support),the symptoms of rhabdosis gradually improved and the patient was discharged.It is suggested that when treating thiamethoxam poisoning,the occurrence of rhabdomyolysis syndrome should be concerned.
作者
吴本鹤
徐敏
陆明峰
赵润敏
Wu Benhe;Xu Min;Lu Mingfeng;Zhao Runmin(Emergency Department of Northern Jiangsu People's Hospital Affiliated to Yangzhou University,Yangzhou 225001,China)
出处
《中华劳动卫生职业病杂志》
北大核心
2025年第7期536-538,共3页
Chinese Journal of Industrial Hygiene and Occupational Diseases
基金
江苏省省级临床重点专科项目(苏卫办医政〔2021〕1号)。
关键词
中毒
噻虫嗪
横纹肌溶解
Poisoning
Thiamethoxam
Rhabdomyolysis
