摘要
新生儿急性呼吸窘迫综合征是指在新生儿期,局部或全身因素诱发出现急性呼吸窘迫,以难治性低氧血症为特征的综合征,诊断常用蒙特勒标准,分度指标推荐使用氧合指数,辅助诊治指标推荐采用肺脏超声评分。治疗方法有高频振荡通气、高剂量肺表面活性物质、吸入一氧化氮、气管内注入布地奈德+肺表面活性物质、俯卧位通气、体外膜肺氧合等。目前仍缺乏更有针对性的治疗方法,中度和重度整体预后欠佳,重度或全身因素导致的新生儿急性呼吸窘迫综合征的病死率相对更高。
Neonatal acute respiratory distress syndrome(ARDS)is a clinical condition characterized by acute respiratory failure with refractory hypoxemia triggered by local or systemic etiologies during the neonatal period.Diagnosis primarily relies on the Montreux criteria.Oxygen index is recommended for grading index and lung ultrasound scoring is recommended for auxiliary diagnosis and treatment index.Current therapeutic strategies include high-frequency oscillatory ventilation,high-dose pulmonary surfactant administration,inhaled nitric oxide,intratracheal instillation of budesonide combined with surfactant,prone positioning,extracorporeal membrane oxygenation.Despite these interventions,targeted therapies remain limited.In particular,neonates with moderate or severe neonatal ARDS generally carry a poor prognosis,with mortality escalating in severe cases or those with systemic etiologies.
作者
张崇巽
李政
高翔羽
Zhang Chongxun;Li Zheng;Gao Xiangyu(Department of Neonatology,Xuzhou Central Hospital(Xuzhou Clinical College of Xuzhou Medical University),Xuzhou 221009,China)
出处
《中华围产医学杂志》
北大核心
2025年第8期711-715,共5页
Chinese Journal of Perinatal Medicine
基金
江苏省研究生实践创新计划(SJCX23_1401)
徐州市科技局重点研发计划(KC22170)。
关键词
呼吸窘迫综合征
急性
诊断
治疗
婴儿
新生
Respiratory distress syndrome,acute
Diagnosis
Treatment
Infant,newborn
