摘要
目的探讨维生素D和血常规免疫相关指标与儿童偏头痛发生的相关性。方法收集2023年1月至2024年9月湖南省第二人民医院收治的偏头痛患儿99例(偏头痛组),选取同期进行健康体检的儿童106例(对照组)作为研究对象。收集两组入选者晨起空腹血液样本,检测并比较两组血液样本中维生素D水平和血常规相关指标以及免疫指标中性粒细胞/淋巴细胞比率(NLR)、单核细胞/淋巴细胞比率(MLR)、血小板/淋巴细胞比率(PLR)之间的差异。分析两组血液样本中维生素D水平和血常规免疫相关指标之间的差异指标与偏头痛的相关性以及与儿童偏头痛发生的危险因素的关系。结果偏头痛组儿童血液样本中维生素D水平、白细胞计数、淋巴细胞值、淋巴细胞比率、嗜酸细胞值、嗜酸细胞比率均显著低于对照组(P<0.05);而中性粒细胞比率、NLR、PLR均显著高于对照组(P<0.05)。儿童血液样本中维生素D水平、白细胞计数、淋巴细胞值、淋巴细胞比率、嗜酸细胞值、嗜酸细胞比率与儿童偏头痛存在负相关性(P<0.05);而中性粒细胞比率、NLR、PLR与儿童偏头痛存在正相关性(P<0.05)。单变量和多变量Logistic回归分析均发现维生素D和淋巴细胞值水平是儿童发生偏头痛的独立危险因素。结论偏头痛组儿童血液样本中维生素D水平和血常规免疫相关指标与对照组有差异,且与儿童发生偏头痛存在相关性;维生素D和淋巴细胞值是儿童偏头痛发生的危险因素。
Objective To explore the correlation between vitamin D and blood routine indicators and the occurrence of migraine in children.Methods 99 Children with migraine patients(migraine group)admitted to the Second People's Hospital of Hunan Province from Jan 2023 to Sep 2024,and 106 children(control group)who underwent health examinations during the same period were collected as the research subjects.The fasting blood samples from two groups of selected individuals in the morning were collected,the levels of vitamin D,blood routine indicators,and inflammatory markers NLR,MLR,and PLR in two groups of blood samples were detected and the differences between them was compared.The correlation between the vitamin D levels and difference indicators between blood routine indicators in blood samples between two groups and migraine,as well as their relationship with risk factors for migraine in children were analyzed.Results The levels of vitamin D,white blood cell count,lymphocyte value,lymphocyte ratio,eosinophil value,and eosinophil ratio in the blood samples of children with migraine were significantly lower than those in the control group(P<0.05),while neutrophil ratio,NLR,and PLR were significantly higher than those in the control group(P<0.05).The levels of vitamin D,white blood cell count,lymphocyte value,lymphocyte ratio,eosinophil value,and eosinophil ratio in children's blood samples were negatively correlated with migraine in children(P<0.05);while the neutrophil ratio,NLR,and PLR in children's blood samples were positively correlated with migraine in children(P<0.05).Univariate and multivariate logistic regression analyses both found that vitamin D levels and lymphocyte value was an independent risk factor for migraine in children.Conclusion The levels of vitamin D and blood routine related indicators in the blood samples of children with migraine were different from those of the control group,and were correlated with the occurrence of migraine in children;Vitamin D and lymphocyte values may be risk factors for migraine in children.
作者
刘霞
杨慧
王琪
黄晨鸣
Liu Xia;Yang Hui;Wang Qi;Huang Chenming(Department of Pediatrics,the Second People's Hospital of Hunan Province(Bain Hospital of Hunan Province),Changsha 410007,China)
出处
《脑与神经疾病杂志》
2025年第8期502-506,共5页
Journal of Brain and Nervous Diseases
基金
湖南中医药大学校级科研项目(自然科学类)(2022XYLH084)
湖南省自然科学基金(2024JJ9352)。
关键词
偏头痛
儿童
维生素D
血常规
免疫
Migraine
Children
Vitamin D
Blood routine
Immunity
