摘要
围绝经期抑郁症因为性腺功能减退,严重影响女性的身心健康,以情绪低落、焦虑不安、思维迟钝、兴趣减退为主要特点,并伴有自主神经功能紊乱和内分泌功能障碍。其发病机制尚不明确且存在争议,诸多学者以围绝经期抑郁动物模型为基础进行科学研究,而良好的围绝经期抑郁动物模型是研究其病理生理机制的基本前提,是可靠科研结果的保障。因此,本文结合国内外围绝经期抑郁的现代研究机制和动物模型的研究现状,对造模方法、原理、结果进行概述、评价和归纳,为科研实验选择合适的动物模型提供科学基础和参考依据。
Perimenopausal depression seriously affects women’s physical and mental health.It is caused primarily by gonadal function decline,which is typically characterized by low mood,anxiety,slow thinking,and loss of interest,and is accompanied by autonomic dysfunction and endocrine dysfunction.The pathogenesis of perimenopausal depression remains unclear and controversial.Many scholars have conducted scientific research that is based on animal models of perimenopausal depression.Indeed,a good animal model of perimenopausal depression is the basic premise for studying its pathophysiological mechanisms and for facilitating reliability of the scientific result.Therefore,this paper combines the modern research mechanisms of perimenopausal depression and the current status of animal models in China,and provides an overview,evaluation,and generalization of the modeling method,principles and result,to provide a scientific basis and reference for the selection of suitable animal models for scientific research experiments.
作者
薛惠
周晓庆
胥阳
隋竹欣
陈熠馨
XUE Hui;ZHOU Xiaoqing;XU Yang;SUI Zhuxin;CHEN Yixin(QILU Medical University,Zibo 255300,China;the Third Hospital Affiliate Guangzhou University of Chinese Medicine,Guangzhou 510378,China)
出处
《中国实验动物学报》
北大核心
2025年第7期1082-1090,共9页
Acta Laboratorium Animalis Scientia Sinica
基金
山东省医药卫生科技发展计划项目(202103090636)。
关键词
围绝经期
抑郁
现代研究机制
动物模型
perimenopause
depression
modern research mechanism
animal model Conflicts of Interest:The authors declare no conflict of interest
