摘要
炎症性肠病(inflammatory bowel disease,IBD)作为一组病因尚不清楚的慢性非特异性肠道炎症疾病,以反复发作的腹泻腹痛、甚至黏液脓血便为主症。朱丹溪从病因病机角度提出以气郁为先的“六郁”(气郁、血郁、痰郁、火郁、湿郁、食郁)理论。从“六郁”理论分析IBD病因病机,主要表现为:气郁为先诱诸病,痰郁、湿郁、食郁伏而待发,火郁肠道炎症发作和血郁日久变生积聚。从“六郁”治IBD肠病,在潜伏期,行气疏肝解郁以消病因,健脾化痰祛湿以复体质;在发作期,清热祛湿抗炎以缓发作;在防癌期,活血化瘀消积以防癌变。
Inflammatory bowel disease(IBD),a group of chronic nonspecific intestinal inflammatory disorders with unclear etiology,is characterized by recurrent symptoms such as diarrhea,abdominal pain,and even mucopurulent or bloody stools.From the perspective of etiology and pathogenesis,Zhu Danxi proposed the Six Stagnations theory(stagnation of qi,blood,phlegm,fire,dampness,and food),which prioritizes qi stagnation as the initiating factor.An analysis of IBD pathogenesis based on the Six Stagnations theory reveals the following mechanisms:qi stagnation acts as the primary trigger,while phlegm,dampness,and food stagnation remain latent and await activation;fire stagnation manifests as intestinal inflammation during acute episodes,and prolonged blood stagnation may lead to the formation of accumulations(pathological masses).Guided by this theory,therapeutic strategies for IBD include:during the latent phase,regulating qi flow,soothing the liver to resolve stagnation(addressing etiology),and fortifying the spleen to resolve phlegm and dispel dampness(restoring constitutional balance);during the active phase,clearing heat,dispelling dampness,and mitigating inflammation to alleviate symptoms;and during the cancer prevention phase,activating blood circulation,resolving stasis,and dispersing accumulations to prevent malignant transformation.
作者
翟浩宇
陈雪
杨冰炜
王成磊
李卫东
ZHAI Haoyu;CHEN Xue;YANC Bingwei;WANG Chengei;LI Weidong(Guang'anmen Hospital,China Academy of Chinese Medical Sciences,Beijing 100053;Shaanxi University of Chinese Medicine;Department of Scientific Research Management,Guang'anmen Hospital,China Academy of Chinese Medical Sciences)
出处
《现代中医临床》
2025年第4期63-67,共5页
Modern Chinese Clinical Medicine
基金
国家自然科学基金面上项目(No.82174464)
中国中医科学院科技创新工程重大攻关项目(No.CI2021A01806)
中央高水平中医医院临床科研业务费资助(No.HLCMHPP2023085)。
关键词
六郁
炎症性肠病
情志
病因病机
防治
Six Stagnations
inflammatory bowel disease
emotion
etiology and pathogenesis
prevention and treatment
