摘要
加巴喷丁类药物(加巴喷丁和普瑞巴林)是带状疱疹后神经痛的一线治疗药物,临床应用广泛。加巴喷丁类药物的体内药动学过程受肾功能影响较大,多数研究表明加巴喷丁和普瑞巴林的体内清除与肾小球滤过率具有显著相关性,因此肾功能减退病人和老年病人需酌情减量使用。加巴喷丁类药物体内过程存在较大个体差异,导致个体差异的原因目前尚无定论。因此,本文将对影响加巴喷丁类药物药动学和药效学变化的因素、个体差异产生的可能原因进行分析和综述,结合加巴喷丁类药物的治疗药物监测和基因多态性检测手段,为带状疱疹后神经痛病人的个体化、精准化治疗提供依据。
Gabapentinoid(gabapentin and pregabalin)is thefirst-line therapeutic drugs for postherpetic neuralgia,and widely used in clinical applications.The clinical application is greatly affected by renal function.Most studies have shown that the removal of gabapentin and pregabalin has a significant correlation with glomerularfiltration rate.Therefore,patients with renal dysfunction and elderly patients should use it in moderation.There are significant individual differences in the internal processes of gabapentinoid,and the reasons for these individual differences are currently inconclusive.Therefore,we will analyze and review the factors that affect the pharmacokinetic and pharmacodynamic changes of gabapentinoid,as well as the possible reasons for individual differences.Combined with the serum therapeutic drug monitoring(TDM)and genetic polymorphism of gabapentinoid,it will provide a basis of personalized and precise treatment for patients with postherpetic neuralgia.
作者
邹杨
支旭然
高丽君
覃旺军
樊碧发
刘湘
ZOU Yang;ZHI Xu-ran;GAO Li-jun;QIN Wang-jun;FAN Bi-fa;LIU Xiang(Department of Pharmacy,China-Japan Friendship Hospital,Beijing 100029,China;Department of Clinical Pharmacy,Xiangtan Central Hospital,Xiangtan 411100,China;Department of Pharmacy,Hebei General Hospital,Hebei Key Laboratory of Clinical Pharmacy Department of Clinical Pharmacy,Shijiazhuang 050000,China;Department of Pharmacy,Beijing Aerospace General Hospital,Beijing 100000,China;Department of Pain Medicine,China-Japan Friendship Hospital,Beijing 100029,China)
出处
《中国疼痛医学杂志》
北大核心
2025年第8期618-623,共6页
Chinese Journal of Pain Medicine
基金
国家重点研发计划“主动健康和人口老龄化科技应对”重点专项(2022YFC3602201)
中日友好医院“菁英计划”人才培育工程(ZRJY2023-GG15)
中央高水平医院临床科研业务费(2022-NHLHCRF-YSPY-02-05)
湖南省卫生健康委员会科研计划项目(D202313018969)。
