摘要
毒理学关注阈值(TTC)是一种风险评估方法,用于确定化学物质的安全暴露阈值,当化学物质的暴露量小于该阈值时,认为其风险可忽略或可接受。2024年5月,中国食品药品检定研究院发布了《毒理学关注阈值(TTC)方法应用技术指南》,该指南首次明确规范了TTC方法用于化妆品安全评估的流程,详细介绍了具体步骤和使用要求。文章对指南的发布背景与意义、TTC方法在化妆品安全评估中的使用原则、TTC方法使用时的注意事项、使用TTC方法对植物提取物原料进行安全评估时的限制条件等进行解读,以期加强指南的指导作用,为更多的从业人员了解、掌握并应用该指南提供参考。
The threshold of toxicological concern(TTC)is a risk assessment methodology used to determine the safe exposure threshold for chemical substances.When the exposed quantity of a chemical substance is below this threshold,the risk is considered negligible or acceptable.The National Institutes for Food and Drug Control released the technical guidelines for the application of TTC method in May 2024,which for the first time explicitly standardizes the process of using the TTC method for cosmetic safety assessment,and details the specific steps and usage requirements.This paper interprets the background and significance of the release of the guide,the principles of its application in cosmetic safety assessment,the precautions when using the TTC method,and the restrictions when using the TTC method for safety assessment of plant extract raw materials.It aims to enhance the guiding role of the guideline and to provide a reference for more practitioners to understand,master,and apply the guideline.
作者
周奕霏
罗飞亚
孙磊
杨会英
裴新荣
吴先富
路勇
Yifei Zhou;Feiya Luo;Lei Sun;Huiying Yang;Xinrong Pei;Xianfu Wu;Yong Lu(National Institutes for Food and Drug Control,Beijing 102629,China)
出处
《日用化学工业(中英文)》
北大核心
2025年第8期1042-1048,共7页
China Surfactant Detergent & Cosmetics
基金
化妆品安全评估关键技术及应用示范研究(RS2024C006)。
关键词
毒理学关注阈值
化妆品安全评估
化妆品原料
风险物质
植物提取物
the threshold of toxicological concern
cosmetic safety assessment
cosmetic raw materials
risk substances
plant extracts
