期刊文献+

莫西沙星治疗新生儿人型支原体脑膜炎的病例分析及文献回顾

Clinical analysis of moxifloxacin in the treatment of neonatal Mycoplasma hominis meningitis and literature review
暂未订购
导出
摘要 目的探讨临床药师在新生儿人型支原体脑膜炎治疗中的作用。方法回顾性分析临床药师参与1例莫西沙星治疗新生儿人型支原体脑膜炎的病例,并系统回顾关于莫西沙星用于新生儿人型支原体脑膜炎的相关文献,分析其临床应用现状与安全性。结果临床药师结合相关文献,通过对莫西沙星用于新生儿人型支原体脑膜炎的风险和获益进行评估,参与抗感染方案的调整与治疗过程的药学监护,患儿最终好转出院。结论在充分评估风险获益后,莫西沙星可作为治疗危及生命或难治性新生儿人型支原体脑膜炎的有效选择。 Objective To investigate the role of clinical pharmacists in the treatment of neonatal Mycoplasma hominis meningitis.Methods Retrospective analysis was performed on a case of moxifloxacin treatment for neonatal Mycoplasma hominis meningitis,in which clinical pharmacists participated,and a systematic review of the literature was conducted to evaluate its clinical application and safety.Results Based on the relevant literature,clinical pharmacists assessed the risks and benefits of moxifloxacin for neonatal Mycoplasma hominis meningitis,participated in the adjustment of anti-infection regimens,and carried out pharmaceutical care during the treatment.The neonate ultimately achieved a stable clinical condition and was discharged.Conclusion Following a comprehensive risk-benefit assessment,moxifloxacin can be used as an effective treatment option for life-threatening or refractory neonatal Mycoplasma hominis meningitis.
作者 张竞佳 张永胜 欧阳珊 Zhang Jingjia;Zhang Yongsheng;Ou Yangshan(Department of Pharmacy,Shenzhen Longhua District Maternal and Child Healthcare Hospital,Shenzhen 518000,China;Department of Pharmacy,Guangzhou Women and Children's Medical Center,Guangzhou 510120,China)
出处 《实用药物与临床》 2025年第8期593-596,共4页 Practical Pharmacy and Clinical Remedies
基金 广东省药学会科学研究基金(2023KJ09)。
关键词 莫西沙星 人型支原体 新生儿 脑膜炎 Moxifloxacin Mycoplasma hominis Neonate Meningitis
  • 相关文献

参考文献5

二级参考文献44

  • 1王宏波,王宇鹏,李皇庆,曾蓉,梁仙志,叶湘漓.长沙地区1409例泌尿生殖道支原体感染者的感染状况及药敏分析[J].中国微生态学杂志,2020,32(2):172-175. 被引量:22
  • 2Tatsumi H, Senda H, Yatera S, et al. Toxicological studies on pipemidic acid. V. Effect on diarthrodial joints of experimental animals[J]. J Toxicol Sci, 1978, 3(4): 357.
  • 3Lim S, Hossain MA, Park J, et al. The effects of enrofloxacin on canine tendon cells and chondrocytes proliferation in vitro[J]. Veterinary Research Communications, 2008, 32(3) :243.
  • 4Takizawa T, Hashimoto K, Minami T, et al. The comparative arthropathy of fluoroquinolones in dogs[J]. Hum Exp Toxicol, 1999,18(6) : 392.
  • 5Menschik M, Neumuller J, Steiner CW, et al. Effects of ciprofloxacin and ofloxacin on adult human cartilage in vitro[J]. Antimicrobial Agents and Chemotherapy, 1997,41 (11):2 562.
  • 6Burkhardt JE, Walterspiel JN, Schaad UB. Quinolone arthropathy in animals versus children[J]. Clin Infect Dis, 1997, 25(5):1 196.
  • 7Lowes DA, Wallace C, Murphy MP, et al. The mitochondria targeted antioxidant Mito Q protects against fluoroquinolone-induced oxidative stress and mitochondrial membrane damage in human Achilles tendon cells[J]. Free Radio Res, 2009,43 (4) : 323.
  • 8Pouzaud F, Dutot M, Martin C, et al. Age-dependent effects on redox status, oxidative stress, mitoehondrial activity and toxicity induced by fluoroquinolones on primary cultures of rabbit tendon cells[J]. Comp Biochem Physiol C Toxicol Pharmacol, 2006,143 ( 2 ) : 232.
  • 9Pouzaud F, Bemard-Beaubois K, Thevenin M, et al. In vitro discrimination of fluoroquinolones toxicity on tendon cells: involvement of oxidative stress[J]. J Pharmacol Exp Ther, 2004, 308( 1 ) : 394.
  • 10Shakibaei M, Kociok K, Forster C, et al. Comparative evaluation of ultrastructural changes in articular cartilage of ofloxacin-treated and magnesium-deficient immature rats[J]. Toxieol Pathol, 1996, 24 (5) : 580.

共引文献206

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部