摘要
在精准医学理念的推动下,早期乳腺癌的治疗模式正逐步走向规范的个体化治疗。在确保治疗效果的基础上,患者的生活质量逐渐受到重视。近年来,随着人表皮生长因子受体2阳性乳腺癌靶向药物、激素受体阳性乳腺癌的细胞周期蛋白依赖性激酶4/6抑制剂及三阴性乳腺癌免疫检查点抑制剂应用的临床研究数据日益丰富,早期乳腺癌的治疗变得更加精准和个性化。此外,保乳、保腋窝甚至豁免原发灶手术的相关临床研究的数据也越来越多,极大改善了患者生活质量。这些更有效的药物和更先进的技术,为早期乳腺癌的降阶梯治疗提供了条件,推动了更为精细化、以患者为中心的治疗模式的进步。
With the advancement of precision medicine,the treatment of early-stage breast cancer is gradually moving toward standardized individualization.While ensuring therapeutic efficacy,increasing attention is being given to patients′quality of life.In recent years,as clinical research data on targeted therapies for HER2-positive breast cancer,CDK4/6 inhibitors for hormone receptor-positive breast cancer,and immune checkpoint inhibitors for triple-negative breast cancer have accumulated,the treatment of early-stage breast cancer has become more precise and personalized.Furthermore,the growing body of clinical research on breast-conserving surgery,axillary preservation,and even the omission of primary tumor resection has significantly improved patients′quality of life.These more effective drugs and advanced technologies provide the foundation for de-escalation treatment strategies in early-stage breast cancer,driving the development of a more refined,patient-centered treatment approach.
作者
郝晓鹏
吴淞
江泽飞
Hao Xiaopeng;Wu Song;Jiang Zefei(Department of General Surgery,First Medical Center of People's Liberation Army General Hospital,Beijing 100853,China;Department of Oncology,Fifth Medical Center of People's Liberation Army General Hospital,Beijing 100071,China)
出处
《中华外科杂志》
北大核心
2025年第8期682-689,共8页
Chinese Journal of Surgery
关键词
乳腺肿瘤
肿瘤治疗方案
靶向治疗
免疫治疗
外科手术
降阶梯治疗
Breastneoplasms
Antineoplasticprotocols
Targeted therapy
Immunotherapy
Surgical procedures,operative
De-escalation therapy
