摘要
目的:了解和分析我院中枢性性早熟患者基本情况及用药合理性。方法:针对2023年1月—2024年1月我院就诊中枢性性早熟患者用药医嘱对患者基本情况、疾病诊断及用药信息进行统计分析。结果:收集我院2023年疾病诊断为中枢性性早熟处方共计5 518份,涉及患儿共计799人,其中男童86人,占比10.76%,女童713人,占比89.24%;BMI<18的患者共计508人,占比63.58%,BMI≥22的患者共计56人,占比7.01%;就诊患儿中年龄集中于8~11岁,共计667人,占比83.48%。中枢性性早熟疾病合并症以肥胖症为主;中枢性性早熟患者用药排名前两位的是注射用醋酸曲普瑞林和注射用醋酸亮丙瑞林缓释微球,其他用药包括维生素D滴剂,重组人生长激素及来曲唑等激素拮抗剂。结论:我院中枢性性早熟患儿就诊人群女性多于男性,中枢性性早熟患儿常合并肥胖症和矮小症,应注重对患儿营养水平和生活方式的调整和改变,避免食用高热量食物、补益药等。用药方面存在不合理和不适宜的情况,应谨慎权衡利弊使用,避免对患儿造成不可逆的影响。
Objective:To understand and analyze the basic situation and medication rationality of patients with central precocious puberty in our hospital.Methods:The basic information,disease diagnosis and medication information of patients with central precocious puberty in our hospital from January 2023 to January 2024 were statistically analyzed.Results:A total of 5518 prescriptions for the diagnosis of central precocious puberty in our hospital in 2023 were collected,involving 799 children,including 86 boys,accounting for 10.76%,and 713 girls,accounting for 89.24%.There were 508 patients with BMI<18,accounting for 63.58%,and 56 patients with BMI≥22,accounting for 7.01%.The age of the children was concentrated in the 8~11 years old,with a total of 667 people,accounting for 83.48%.Obesity is the main complication of central precocious puberty.The top two drugs for patients with central precocious puberty were triptorelin acetate for injection and leuprolide acetate sustained-release microspheres for injection.Other drugs included vitamin D drops,recombinant human growth hormone and letrozole and other hormone antagonists.Conclusion:The number of female patients with central precocious puberty in our hospital is more than that of male patients.Children with central precocious puberty are often complicated with obesity and short stature.We should pay attention to the adjustment and change of children's nutritional level and lifestyle,and avoid eating high-calorie foods,tonics,etc.There are unreasonable and inappropriate situations in the use of drugs,and the use of advantages and disadvantages should be carefully weighed to avoid irreversible effects on children.
作者
李灵琦
黄艳
肖爱萍
LI Lingqi;HUANG Yan;XIAO Aiping(Department of Pharmacy,the First Affiliated Hospital of Xiamen University School of Medicine,Xiamen,Fujian 361000,China)
出处
《农垦医学》
2025年第3期261-264,276,共5页
Journal of Nongken Medicine
