摘要
目的探讨肝动脉灌注化疗(hepatic arterial infusion chemotherapy,HAIC)联合程序性死亡受体(PD-1)抑制剂及抗血管生成药物对BCLC C期肝细胞癌(HCC)的疗效。方法选择2021年1月至2023年12月苏州大学附属第一医院经HAIC联合PD-1抑制剂及抗血管生成药物治疗的BCLC C期HCC患者。分析治疗至达到完全缓解(CR)的时间,随访期间AFP的动态变化和复发情况。通过PubMed检索上述三联方案治疗HCC的相关文献并进行分析。结果在214例接受三联方案治疗的HCC患者中,9例(4.2%)达到CR。9例患者从首次治疗至达到CR的时间为2~10个月。随访5~20个月,AFP降至正常的时间为79~259 d。1例于10个月后复发,余8例保持CR状态。共检索到12篇相关文献,CR率为0~16.5%。结论HAIC联合PD1抑制剂及抗血管生成药物治疗晚期HCC,少数患者可达到CR,且该效果的发生是急速过程。
Objective To discuss the curative effect of hepatic arterial infusion chemotherapy(HAIC)combined with programmed death receptor-1(PD-1)inhibitors and anti-angiogenesis therapy for BCLC stage C hepatocellular carcinoma(HCC).Methods The patients with HCC of BCLC stage C,who received HAIC combined with PD-1 inhibitors and anti-angiogenesis therapy at the First Affiliated Hospital of Soochow University of China from January 2021 to December 2023,were collected for this study.The time from the start of treatment to complete remission(CR)of disease,the dynamic changes in alpha-fetoprotein(AFP)levels and the recurrence during follow-up period were analyzed.The relevant literature of the above triple regimen for HCC was searched from PubMed database and its curative effect was analyzed.Results Of the 214 HCC patients treated with triple therapy regimen,9(4.2%)achieved CR.The time from the start of treatment to CR was 2-10 months.The patients were followed up for 5-20 months.The time of AFP level returning to normal value was from79 to 259 days.One patient developed recurrence 10 months after CR,and the other 8 patients maintained the CR status.A total of 12 articles were retrieved,the reported CR rates ranged from0to 16.5%.Conclusion A CR can be achieved in a few patients with advanced HCC treated with HAIC combined with PD-1inhibitors and anti-angiogenesis therapy.
作者
卢世涛
郭亚潘
冯文聪
杨俊
印于
李智
LU Shitao;GUO Yapan;FENG Wencong;YANG Jun;YIN Yu;LI Zhi(Department of Interventional Radiology,First Affiliated Hospital of Soochow University,Suzhou,Jiangsu Province 215000,China)
出处
《介入放射学杂志》
北大核心
2025年第7期724-729,共6页
Journal of Interventional Radiology
基金
苏州市“科教强卫”面上项目(MSXM2024002)
苏州市应用基础研究计划——医疗卫生(青年)项目(SYW2024165)。
关键词
肝细胞癌
肝动脉灌注化疗
PD1抑制剂
抗血管生成治疗
完全缓解
hepatocellular carcinoma
hepatic arterial infusion chemotherapy
PD-1 inhibitor
antiangiogenesis therapy
complete Remission
