摘要
心血管疾病是全球最主要的死亡原因之一,其中心肌重构是大多数心血管疾病发生发展的核心。嘌呤能配体门控离子通道7受体(P2X7R)是嘌呤能受体家族成员之一,它在免疫细胞、心肌平滑肌细胞和内皮细胞中表达,在免疫系统调节、神经保护和炎症反应等相关的病理过程中起着重要作用。P2X7R的激活在心肌重构中发挥重要作用,包括心肌纤维化、心肌肥大及心力衰竭。因此,该文对P2X7R的结构、功能特性以及其在心肌重构中的作用机制进行综述。
Cardiovascular disease is one of the leading causes of death worldwide,and myocardial remodeling is at the core of the development and progression of most cardiovascular diseases.Purinergic ligand-gated ion channel 7 receptor(P2X7R)is a member of the purinergic receptor family,which is expressed in immune cells,cardiac smooth muscle cells,and endothelial cells,and plays an important role in pathological processes related to immune system regulation,neuroprotection,and inflammatory responses.Activation of P2X7R plays an important role in myocardial remodeling,including myocardial fibrosis,myocardial hypertrophy,and heart failure.Therefore,this article reviews the structural and functional properties of P2X7R and its mechanism of action in myocardial remodeling.
作者
杨莎莎(综述)
莫莉花
王辉波(审校)
Yang Shasha;Mo Lihua;Wang Huibo(Institute of Cardiovascular Diseases,China Three Gorges University,Yichang 443003;Dept of Cardiology,First Clinical Medical College,China Three Gorges University,Yichang 443003)
出处
《安徽医科大学学报》
北大核心
2025年第7期1359-1364,共6页
Acta Universitatis Medicinalis Anhui
基金
国家自然科学基金(编号:82100270)
2023年三峡大学国家中医药管理局中药药理科研三级实验室开放基金课题(编号:2023PTCM06)。
关键词
P2X7R
心血管疾病
心肌重构
心肌纤维化
心肌肥大
心力衰竭
P2X7R
cardiovascular disease
cardiac remodeling
myocardial fibrosis
myocardial hypertrophy
heart failure
