摘要
目的 探讨茚达特罗格隆溴铵对稳定期慢性阻塞性肺疾病(COPD)患者肺功能和圣乔治呼吸问卷(SGRQ)评分的影响。方法 选取2022年4月至2024年4月湖州市第一人民医院诊治的稳定期COPD患者160例,随机数字表法分为治疗组和对照组各80例,对照组使用沙美特罗替卡松吸入粉雾剂,每次1吸,每日2次,治疗组使用茚达特罗格隆溴铵吸入粉雾剂,每次1粒,每日1次,共治疗3个月。比较两组临床疗效、肺功能指标、血清炎症因子、心理恢复力和生活质量。结果 治疗期间对照组脱落5例,治疗组脱落3例,最终对照组75例,治疗组77例完成研究。治疗组显效53例,有效16例,总有效率89.61%;对照组显效40例,有效18例,总有效率77.33%。治疗后两组第1秒用力呼气容积(FEV1)、用力肺活量(FVC)和FEV1占预测值的百分比(FEV1%)较前升高,肿瘤坏死因子-α(TNF-α)、IL-6、C反应蛋白(CRP)和降钙素原(PCT)均较前降低,弹性评分、强度评分、乐观评分和Connor-Davidson心理弹性量表总分均较前升高,症状评分、活动评分、影响评分和圣乔治呼吸问卷总分均较前降低,且治疗组上述指标较对照组改善更为明显。结论 茚达特罗格隆溴铵治疗稳定期COPD可增强患者肺功能,缓解气道炎症反应,提高临床疗效,增强心理弹性,提高生活质量。
Objective To evaluate the effects of indacaterol/glycopyrronium on lung function and St.George's Respiratory Questionnaire(SGRQ)scores in patients with stable chronic obstructive pulmonary disease(COPD).Method A total of 160 patients with stable COPD(April 2022 to April 2024)in Huzhou First People's Hospital were randomly assigned to either the treatment group(n=80)receiving indacaterol/glycopyrronium inhalation powder(one inhalation once daily)or the control group(n=80)receiving salmeterol/fluticasone inhalation powder(one inhalation twice daily)for 3 months.Outcomes included clinical efficacy,lung function,serum inflammatory markers,psychological resilience(Connor-Davidson Resilience Scale,CD-RISC),and quality of life.Results During the treatment,5 cases fell off in the control group,3 cases fell off in the treatment group,75 cases in the final control group,and 77 cases in the treatment group completed the study.In the treatment group,53 cases were significantly effective,16 cases were effective,the total effective rate was 89.61%.In the control group,40 cases were significantly effective,18 cases were effective,the total effective rate was 77.33%.After treatment,forced expiratoty volume insecend(FEV1),forced vital capacity(FVC),FEV1/FVC,and FEV1%in both groups increased compared to before treatment,while tumor necrosis factor-α(TNF-α),IL-6,C-reactive protein(CRP),and procalcitonin(PCT)decreased.Elasticity score,intensity score,optimism score,and Connor-Davidson Resilience Scale(CD-RISC)total score all increased compared to before treatment.Symptom score,activity score,impact score,and St.George's Respiratoty Questunnaive(SGRQ)total score all decreased compared to before treatment,and the above indicators in the treatment group improved more significantly than those in the control group.Conclusion The treatment of stable COPD indacaterol/glycopyrronium significantly enhances lung function,reduces systemic inflammation,improves clinical efficacy,increases psychological resilience,and elevates quality of life in stable COPD patients compared to salmeterol/fluticasone.
作者
陆溦
姚伟
潘慧斌
LU Wei;YAO Wei;PAN Huibin(Department of Respiratory Medicine,Huzhou First People's Hospital,Zhejiang Huzhou 313000,China;Department of Emergency,Huzhou First People's Hospital,Zhejiang Huzhou 313000,China)
出处
《临床药物治疗杂志》
2025年第7期57-62,共6页
Clinical Medication Journal
基金
湖州市科学技术项目(2024GZ83)。
关键词
慢性阻塞性肺疾病
圣乔治呼吸问卷
茚达特罗
格隆溴铵
心理弹性量表
chronic obstructive pulmonary disease
St.George's Respiratory Questionnaire
indacaterol
glycopyrronium
Connor-Davidson Resilience Scale
