摘要
利非司特是一种新型小分子整合素抑制剂,通过抑制淋巴细胞功能相关抗原1(LAF-1)与细胞间黏附分子1(ICAM-1)结合,抑制炎症级联反应,降低由T淋巴细胞介导的干眼炎性反应水平。该药2016年在美国上市,并于2018年纳入美国眼科协会(AAO)干眼治疗实践指南中。2023年12月被列入国家卫生健康委等6部门发布的《第三批鼓励仿制药品目录》名单中,2025年6月利非司特滴眼液获批在国内上市。本文对利非司特滴眼液的国内外研究资料进行系统梳理,从药效学、药动学、临床疗效以及安全性等不同的角度进行概述,旨在为临床安全合理用药提供参考。
Lifitegrast is a novel small molecule integrin inhibitor that inhibits T-cell-mediated inflammation in dry eye disease(DED)by blocking the conformational activation of lymphocyte function-associated antigen-1(LFA-1)and its binding to intercellular adhesion molecule-1(ICAM-1).Lifitegrast ophthalmic solution were first approved in the United States in 2016 and was included in the American Academy of Ophthalmology(AAO)dry eye treatment practice guidelines in 2018.In December 2023,it was included in the list of the“Third Batch of Encouraged Generic Drugs”released by the National Health Commission and five other departments.In June 2025,lifitegrast ophthalmic solution were approved for listing in China.This article systematically reviews the domestic and international research data on lifitegrast ophthalmic solution from different perspectives such as pharmacology,pharmacokinetics,clinical efficacy,and safety,in order to provide a reference for the safe and rational use of the drug in clinical practice.
作者
张然
封昭
张丽霞
武丹蕾
接英
陈有信
孙兴怀
ZHANG Ran;FENG Zhao;ZHANG Lixia;WU Danlei;JIE Ying;CHEN Youxin;SUN Xinghuai(Beijing Pharmaceutical Association,Beijing 100120,China;Department of Ophthalmology,Eye Hospital China Academy of Chinese Medical Sciences,Beijing 100040,China;Department of Ophthalmology,Guang'anmen Hospital China Academy of Chinese Medical Sciences,Beijing 100053,China;Department of Ophthalmology,Beijing Tongren Hospital,Capital Medical University,Beijing 100730,China;Department of Ophthalmology,Peking Union Medical College Hospital,Chinese Academy of Medical Sciences&Peking Union Medical College,Beijing 100730,China;Eye&ENT Hospital of Fudan University,Shanghai 200031 China)
出处
《临床药物治疗杂志》
2025年第7期15-18,共4页
Clinical Medication Journal
关键词
干眼
淋巴细胞功能相关抗原1
细胞间黏附分子1
利非司特滴眼液
dry eye disease
lymphocyte function associated antigen-1
intercellular cell adhesion molecule-1
lifitegrast ophthalmic solution
