摘要
青蒿素(Ⅰ)是我国科学工作者近年来从中药青蒿(菊科植物黄花蒿Artemisia annua L.)中分离得到的具有新型化学结构的抗疟药。几年来的临床试验证明,青蒿素对治疗各类型疟疾具有速效、低毒等优点,并对治疗抗氯喹疟原虫株病人有效;不少地区已将青蒿素作为抡救凶险型疟疾病人的首选药物。其主要缺点是近期复燃率较高,为了寻找疗效好、复燃率小的新化合物,我们对青蒿素进行了一系列的结构改造。
Artemisinine,a new antimalarial drug,has been discovered recently by scientists in China.In order to find more potent antimalarials,we have synthesized over 30 derivatives of artemisinine,i.e.ethers,esters,and carbonates of dihydroartemisinine prepared by treatment of artemisinine with sodium borohydride.They have been evaluated against chloroquine-resistant strain of P.berghei in mice.It has been demonstrated that many of these synthesized compounds are much more potent than artemisinine.
作者
李英
虞佩琳
陈一心
李良泉
盖元珠
王德生
郑亚平
LI YING;YU PEI-LIN;CHEN YIXIN;LI LIANG-QUAN;GAI YUAN-ZHU;WANG DE-SHENG;ZHENG YA-PING
出处
《科学通报》
1979年第14期667-669,共3页
Chinese Science Bulletin
