摘要
幽门螺杆菌(Helicobacter pylori,H.pylori)主要定植于人体胃内,是多种胃肠道疾病的重要病原体,也是胃癌的高危因素。目前,抗H.pylori治疗主要采用抑酸剂联合抗生素,但治疗效果常因耐药性增强、不良反应多及患者依从性差而不佳。基于上述问题,越来越多的研究采用益生菌作为H.pylori根除治疗的辅助手段。布拉氏酵母菌是一种抗酸和抗生素的非致病性真菌,可安全地与常规根除治疗同时使用。本文系统地总结了布拉氏酵母菌的抗菌机制,以及其应用于各种初次和二次根除方案及特殊人群治疗H.pylori感染的效果,以期让临床医师更好地掌握该益生菌的治疗作用、安全性及给药方案,从而制定个体化的治疗策略。
Helicobacter pylori(H.pylori)is mainly colonized in the human stomach.It is an important pathogen of a variety of gastrointestinal diseases,but also a high risk factor for gastric cancer.At present,the anti-H.pylori treatment mainly uses acid suppressors combined with antibiotics,but the therapeutic effect is often poor due to increased drug resistance,more adverse reactions and poor patient compliance.Based on the above problems,more and more studies have adopted probiotics as an auxiliary means of H.pylori eradication therapy.Saccharomyces boulardii is a non-pathogenic fungus that is resistant to acids and antibiotics and can be safely used in conjunction with conventional eradication treatments.In this review,the antibacterial mechanism of Saccharomyces boulardii was systematically summarized,as well as the effects of its application in various primary and secondary eradication programs and special populations in the treatment of H.pylori infection,in order to enable clinicians to better grasp the therapeutic effect,safety and administration of this probiotic,so as to formulate individualized treatment strategies.
作者
黄文莎
张圣杰
季梦遥
沈磊
HUANG Wensha;ZHANG Shengjie;JI Mengyao;SHEN Lei(Department of Gastroenterology,Renmin Hospital of Wuhan University,Wuhan 430000,China)
出处
《胃肠病学和肝病学杂志》
2025年第7期1061-1066,共6页
Chinese Journal of Gastroenterology and Hepatology
基金
国家自然科学基金(81901817)。
关键词
布拉氏酵母菌
幽门螺杆菌
益生菌
根除治疗
Saccharomyces boulardii
Helicobacter pylori
Probiotics
Eradication therapy
