摘要
溃疡性结肠炎(ulcerative colitis,UC)是一种慢性的炎症性肠病(inflammatory bowel disease,IBD),具有反复发作和缓解的特征。尽管临床上有多种治疗方法,但由于疾病的异质性和复杂性,个体间的治疗反应和药物耐受性存在显著差异,很多患者的病情依旧不稳定。随着再生医学的快速发展,肠类器官的培养技术为UC个性化治疗提供了新的视角,成为研究肠道生理和疾病的有力工具。本文集中探讨了肠干细胞移植以及肠类器官的最新进展。
Ulcerative colitis(UC)is a chronic inflammatory bowel disease(IBD)characterized by recurrent episodes and retreats.Although there are a variety of clinical treatment methods,due to the heterogeneity and complexity of the disease,there are significant differences in treatment response and drug tolerance among individuals,and the condition of many patients remains unstable.With the rapid development of regenerative medicine,the culture technology of intestinal organoids provides a new perspective for the personalized treatment of UC,and becomes a powerful tool for the study of intestinal physiology and diseases.This review focused on the recent progress of intestinal stem cell transplantation and intestinal organoids.
作者
崔璐
郝玉霞
CUI Lu;HAO Yuxia(Department of Gastroenterology,Shanxi Provincial People's Hospital,Shanxi Medical University,Taiyuan 030012,China)
出处
《胃肠病学和肝病学杂志》
2025年第7期946-949,共4页
Chinese Journal of Gastroenterology and Hepatology
基金
山西省回国留学人员科研资助项目(2024-153)。
关键词
结肠类器官
肠干细胞
溃疡性结肠炎
Colonic-like organ
Intestinal stem cells
Ulcerative colitis
