摘要
目的探讨遗体供肾硬度与低温机械灌注(hypothermic machine perfusion,HMP)参数之间的相关性,为供肾质量评估提供新的量化指标,并优化供肾选择标准。方法本研究使用邵氏硬度计对2024年10月1日至2024年11月30日期间获取的58例遗体捐献供肾的硬度进行量化测量,分别在灌注前、后测量肾脏硬度,并记录低温机械灌注的流量和阻力指数。通过Pearson相关分析方法,分析供肾硬度与HMP参数之间的相关性。结果灌注前肾脏硬度与HMP流量呈负相关(r=-0.544,P<0.001),与阻力指数呈正相关(r=0.745,P<0.001)。灌注后肾脏硬度与流量呈负相关(r=-0.477,P<0.001),与阻力指数呈正相关(r=0.701,P<0.001)。灌注前后肾脏硬度差值与流量呈正相关(r=0.459,P<0.001),与阻力指数呈负相关(r=-0.524,P<0.001)。结论供肾硬度与HMP的流量和阻力指数之间存在显著相关性,硬度较高的肾脏可能伴有微血管损伤或组织纤维化,导致灌注时血流阻力增加、流量减少。邵氏硬度计为供肾质量评估提供了客观、量化的指标,结合HMP参数,有望优化供肾选择标准,提高移植成功率。
Objective To explore the correlation between deceased donor kidney hardness and hypothermic machine perfusion(HMP)parameters,providing a new quantitative indicator for assessing kidney quality and optimizing donor kidney selection criteria.Methods This study used a Shore hardness tester to quantitatively measure the hardness of 58 donated kidneys obtained from October 1,2024 to November 30,2024.Measurements were conducted both pre-and post-perfusion,and the flow rate and resistance index(RI)of HMP were systematically recorded.Pearson correlation analysis was utilized to evaluate the relationship between kidney hardness and HMP parameters,providing a robust statistical framework for understanding their interdependencies.Results Pre-perfusion kidney hardness demonstrated a significant negative correlation with HMP flow rate(r=-0.544,P<0.001)and a significant positive correlation with the resistance index(RI,r=0.745,P<0.001).Similarly,post-perfusion kidney hardness showed a significant negative correlation with flow rate(r=-0.477,P<0.001)and a significant positive correlation with RI(r=0.701,P<0.001).Furthermore,the difference in kidney hardness before and after perfusion exhibited a significant positive correlation with flow rate(r=0.459,P<0.001)and a significant negative correlation with RI(r=-0.524,P<0.001).Conclusion There exists a significant correlation between donor kidney hardness and both flow rate and RI in HMP.Kidneys with higher hardness may be associated with microvascular injury or tissue fibrosis,leading to increase perfusion resistance and reduce flow rate during perfusion.The Shore durometer provides an objective and quantitative metric for assessing donor kidney quality.When combines with HMP parameters,it holds promise for optimizing donor kidney selection criteria and improving transplant success rates.
作者
陈国振
刘海平
汪帆
丁晨光
薛武军
Chen Guozhen;Liu Haiping;Wang Fan;Ding Chenguang;Xue Wujun(The First Affiliated Hospital of Xi'an Jiaotong University,Department of Organ Donation,Shaanxi Xi'an 710061,China;Department of Kidney Transplantation,Kidney Disease Hospital,The First Affiliated Hospital of Xi'an Jiaotong University,Institute of Organ Transplantation,Xi'an Jiaotong University,Shaanxi Xi'an 710061,China.)
出处
《实用器官移植电子杂志》
2025年第4期307-312,共6页
Practical Journal of Organ Transplantation(Electronic Version)
基金
中国人体健康科技促进会专项课题(JKHY-Z2023001-04)。
关键词
邵氏硬度计
低温机械灌注
肾脏硬度
相关性
Shore durometer
Hypothermic machine perfusion
Kidney hardness
Correlation
