摘要
目的探讨人体腰椎骨髓脂肪含量与增龄的相关性。材料与方法前瞻性纳入135名志愿者,年龄跨度30~79岁,使用磁共振IDEL-IQ序列测量其腰椎脂肪分数(fat fraction,FF),按照10岁间隔将受试者分成30+~70+组,分析L3椎体及腰椎平均FF(FF_(L3)、FF_(A))在不同年龄组间的差异及变化趋势,并分析其与年龄的相关性。结果对于全体受试者,男女性组间年龄、L1~L5及平均FF差异均无统计学意义(P>0.05);经过年龄分割后,男女性FF_(L3)及FF_(A)均表现出随增龄而增加的趋势(P<0.05),男女性组间FF差异在50+、70+组无统计学意义(P>0.05),30+组及40+组男性高于女性、60+组男性低于女性(P<0.05);较前一年龄组,男性受试者腰椎FF在70岁后出现快速增长(P<0.05),而女性则在50岁后出现快速增长(P<0.05)、70岁后增速相对减缓(P>0.05);男性FF_(L3)及FF_(A)均与增龄呈中度线性正相关(r=0.516、0.553,P<0.05),而女性呈强线性正相关(r=0.777、0.780,P<0.001)。结论男女性腰椎骨髓脂肪含量及随增龄的变化趋势有所不同,女性50岁、男性70岁后出现快速增长,两者均与增龄密切相关。
Objective:To investigate the correlation between bone marrow fat fraction(FF)of human lumbar spine and aging.Materials and Methods:A prospective cohort of 135 volunteers,ranging in age from 30 to 79 years,were recruited to measure the lumbar FF using IDEAL-IQ technology based on magnetic resonance imaging.The subjects were divided into 30+ to 70+ groups according to the interval of 10 years old.The differences and trends of L3 and average FF of lumbar spine(FF_(L3)&FF_(A))in different age groups were analyzed.The correlation between bone marrow fat content of lumbar vertebrae and age was analyzed.Results:For all subjects,there was no significant difference in age,L1-L5 and average FF between males and females(P>0.05).After age segmentation,both FF_(L3) and FF_(A) showed an increasing trend with age in both males and females(P<0.05).The differences between male and female groups were not statistically significant in the 50+and 70+groups(P>0.05).In 30+group and 40+group,FF_(L3) and FF_(A) of the male were significantly higher than female;while in 60+group,the male was significantly lower(P<0.05).Compared to the previous age group,FFL3 and FFA of male subjects increased rapidly after 70 years of age(P<0.05).Women,on the other hand,grew rapidly after the age of 50(P<0.05)and slowed down after the age of 70(P>0.05).Both FF_(L3) and FF_(A) were moderately linearly positively correlated with aging in males(r=0.516,0.553,respectively,P<0.05)and strongly correlated with aging in females(r=0.777,0.780,respectively,P<0.001).Conclusions:The bone marrow fat content of male and female lumbar spine show different trends with aging,but both are closely related to it,with rapid growth observed in females after the age of 50 and males after the age of 70.
作者
赵青
胡春洪
陶剑
张跃
单奔
ZHAO Qing;HU Chunhong;TAO Jian;ZHANG Yue;SHAN Ben(Department of Radiology,the Affiliated Huaian Hospital of Xuzhou Medical University/Huaian Second People's Hospital,Huaian 223001,China;Department of Radiology,the First Affiliated Hospital of Soochow University,Suzhou 215006,China;Department of Radiology,Huaian Hospital Affiliated to Yangzhou University,the Fifth People's Hospital of Huaian,Huaian 223300,China)
出处
《磁共振成像》
北大核心
2025年第8期100-105,共6页
Chinese Journal of Magnetic Resonance Imaging
基金
淮安市卫生健康科研项目(编号:HAWJ202116)
江苏护理职业学院科教融汇临床科研项目(编号:SH202410250302)
淮安市“淮上英才计划”培育项目(编号:HA2022C1029)。
