摘要
病毒样颗粒(virus-like particles,VLP)疫苗作为一种新兴的疫苗技术,因其安全性高、免疫原性强,在传染病防控领域展现了巨大的潜力,能有效激发机体的免疫反应。随着生物技术的快速发展,VLP疫苗的研究和应用取得了较为显著进展,成为疫苗领域的一个重要方向。本文从VLP疫苗的优势,免疫机制,表达系统(细菌、酵母以及植物、昆虫和哺乳动物细胞等)及其在禽病防控中的应用方面进行综述,旨在为禽病VLP疫苗的研发提供参考。随着技术进步和防控需要,VLP疫苗有望在禽类疫病防控实践中发挥重要的作用。
Virus-like particles(VLP)vaccines represent an emerging technology with huge potential in the prevention and control of infectious disease,due to their high safety and strong immunogenicity,effectively stimulating immune response in organisms.With rapid development of biotechnology,VLP vaccines,as a pivotal direction,have been greatly advanced in the fields of research and application.Here,the advantages of VLP vaccines,their immune mechanisms and expression systems including bacterial,yeast,plant,insect and mammalian cells systems,as well as their application in the prevention and control of avian diseases were reviewed,for the purpose of guiding future research and development of VLP vaccines against the diseases.It was expected that,with technological advances and the needs for disease prevention and control,VLP vaccines would play an important role in the field.
作者
郭通
王海鸣
王静静
刘华雷
Guo Tong;Wang Haiming;Wang Jingjing;Liu Hualei(China Anima1 Health and Epidemiology Center,Qingdao 266032,Shandong,China;Qingdao Agricultural University,Qingdao 266109,Shandong,China;Ningxia University,Yinchuan 750000,Ningxia,China;Key Laboratory of Animal Biosafety Risk Warning,Prevention and Control(Southem China),Ministry of Agriculture and Rural Affairs,Qingdao 266032,Shandong,China)
出处
《中国动物检疫》
2025年第8期86-93,共8页
China Animal Health Inspection
基金
国家重点研发计划项目(2022YFD1800600)。
关键词
病毒样颗粒疫苗
优势
免疫机制
表达系统
防控应用
VLP
advantage
immune mechanism
expression system
application in prevention and control
