摘要
目的 探讨血清胆碱酯酶、N末端脑钠肽前体(NT-proBNP)、中枢神经特异蛋白(S100β)水平与急性有机磷中毒患者临床预后的关系。方法 选取2021年1月—2024年1月江苏省南通市海安市人民医院收治的急性有机磷中毒患者102例,根据预后分为死亡组22例和存活组80例,比较两组患者的血清胆碱酯酶、NT-proBNP、S100β水平,分析血清胆碱酯酶、NT-proBNP、S100β对急性有机磷中毒患者预后的影响,评价血清胆碱酯酶、NT-proBNP、S100β对急性有机磷中毒患者预后的预测价值。结果 死亡组患者的中毒至入院时间、急性生理与慢性健康状态评分(APACHEⅡ)、NT-proBNP、S100β高于存活组,白蛋白、血清胆碱酯酶水平低于存活组(P<0.05)。血清胆碱酯酶(OR=0.201,95%CI:0.080~0.503)、NT-proBNP(OR=3.684,95%CI:1.473~9.216)、S100β(OR=3.579,95%CI:1.430~8.953)是急性有机磷中毒患者预后死亡的影响因素(P<0.05)。血清胆碱酯酶、NT-proBNP、S100β预测急性有机磷中毒患者预后的灵敏度分别为0.82、0.77、0.78、0.86,特异度分别为0.73、0.80、0.69、0.83,曲线下面积分别为0.784(95%CI:0.708~0.861)、0.772(95%CI:0.691~0.854)、0.759(95%CI:0.683~0.841)、0.871(95%CI:0.816~0.931)。结论 血清胆碱酯酶、NT-proBNP、S100β可用于预测急性有机磷中毒患者的预后,预测价值良好。
Objective To explore the relationship between serum cholinesterase,N-terminal pro brain natriuretic peptide(NT-proBNP),S100 calcium-binding proteinβ(S100β)levels and clinical prognosis in patients with acute organophosphate poisoning.Methods 102 patients with acute organophosphate poisoning admitted to the hospital from January 2021 to January 2024 were selected and divided into a death group of 22 cases and a survival group of 80 cases based on prognosis.The serum levels of cholinesterase,NT-proBNP,and S100βwere compared between the two groups of patients,and the impact of serum cholinesterase,NT-proBNP,and S100βon the prognosis of acute organophosphate poisoning patients was analyzed.The predictive value of serum cholinesterase,NT-proBNP,and S100βon the prognosis of acute organophosphate poisoning patients was evaluated.Results The time from poisoning to admission,acute physiology and chronic health status score(APACHEII),NT-proBNP,S100βwere higher in the death group than in the survival group,while albumin and serum cholinesterase levels were lower in the survival group(P<0.05).Serum cholinesterase(OR=0.201,95%CI:0.080-0.503),NT-proBNP(OR=3.684,95%CI:1.473-9.216),and S100β(OR=3.579,95%CI:1.430-8.953)are prognostic factors affecting mortality in patients with acute organophosphate poisoning(P<0.05).The sensitivity of serum cholinesterase,NT-proBNP,and S100βin predicting the prognosis of patients with acute organophosphate poisoning were 0.82,0.77,0.78,and 0.86,respectively.The specificity was 0.73,0.80,0.69,and 0.83,respectively.The area under the curve was 0.784(95%CI:0.708-0.861),0.772(95%CI:0.691-0.854),0.759(95%CI:0.683-0.841),and 0.871(95%CI:0.816-0.931),respectively.Conclusion Serum cholinesterase,NT-proBNP,and S100βcan be used to predict the prognosis of patients with acute organophosphate poisoning,showing good predictive value.
作者
吉庆根
吴兆华
黄晓勇
JI Qinggen;WU Zhaohua;HUANG Xiaoyong(Department of Emergency,Hai’an People’s Hospital,Nantong Jiangsu 226600,China)
出处
《中国急救复苏与灾害医学杂志》
2025年第8期1048-1051,共4页
China Journal of Emergency Resuscitation and Disaster Medicine
基金
江苏省自然科学基金面上项目(BK20221522)。
关键词
急性有机磷中毒
胆碱酯酶
N末端脑钠肽前体
中枢神经特异蛋白
预后
Acute organophosphate poisoning
Cholinesterase
N-terminal pro brain natriuretic peptide
S100 calcium-binding proteinβ
Prognosis
