摘要
目的 探讨高迁移率族蛋白B1(HMGB1)、白细胞介素-8(IL-8)与急性缺血性脑卒中(AIS)患者静脉溶栓治疗后短期临床预后的关系。方法 本研究使用比较研究法,纳入2020年1月—2023年6月在南京医科大学第四附属医院神经内科接受静脉溶栓治疗的AIS患者。基于改良Rankin量表(mRS)评估的结局差异,受试者被归类为预后良好组和预后不良组。采集两组患者的基本临床资料实验室检测结果、就诊时长、脑梗死类型及相关血管情况等,对以上因子行单因素和多因素Logistic回归分析,探讨其与静脉溶栓后30 d预后不良的关系。结果 共有202例病患被纳入30 d预后分析中,其中有107例预后良好,95例预后不良,分别占总数的52.97%和47.03%。高龄、高血压、颅内水肿、颅内出血、美国国立卫生研究院率中量表(NIHSS)评分、白细胞计数、梗死体积、HMGB1及IL-8对AIS静脉溶栓30 d临床预后产生独立影响(P<0.05)。受试者工作特征(ROC)曲线结果显示,HMGB1、IL-8是AIS静脉溶栓治疗30 d预后不良的独立危险因素。结论 HMGB1和IL-8可对接受静脉溶栓治疗的AIS患者临床预后起到预测作用,HMGB1和IL-8水平越高,AIS患者接受静脉溶栓治疗的预后就越差。
Objective To investigate the relationship between high mobility group box 1(HMGB1),interleukin-8(IL-8),and the short-term clinical outcomes of acute ischemic stroke(AIS)patients after intravenous thrombolysis(IVT)treatment.Methods This comparative study included AIS patients treated with IVT in the Department of Neurology at the Fourth Affiliated Hospital of Nanjing Medical University from January 2020 to June 2023.Patients were divided into two groups based on the modified Rankin scale(mRS):the good prognosis group and the poor prognosis group.Basic information,laboratory test results,duration of medical consultation,type of cerebral infarction,and related vascular conditions were collected and analyzed.Univariate and multivariate logistic regression analyses were performed to explore the factors associated with poor prognosis 30 days after IVT.Results A total of 202 patients were included in the 30-day prognosis analysis,with 107 having a good prognosis and 95 having a poor prognosis,accounting for 52.97%and 47.03%,respectively.Advanced age,hypertension,cerebral edema,intracranial hemorrhage,NIHSS score,white blood cell count,infarct volume,HMGB1,and IL-8 independently affected the 30-day clinical outcomes of AIS patients undergoing IVT(P<0.05).ROC curve analysis showed that HMGB1 and IL-8 are independent risk factors for poor prognosis at 30 days post-IVT.Conclusion HMGB1 and IL-8 are predictive factors for the clinical outcomes of AIS patients treated with IVT.Higher levels of HMGB1 and IL-8 are associated with worse prognosis in AIS patients receiving IVT treatment.
作者
王宇
吴丽玲
熊军
储著凤
WANG Yu;WU Liling;XIONG Jun;CHU Zhufeng(Department of Neurology,Fourth Affiliated Medical University,Nanjing Jiangsu 210031,China)
出处
《中国急救复苏与灾害医学杂志》
2025年第8期1044-1047,共4页
China Journal of Emergency Resuscitation and Disaster Medicine
基金
江苏省科技计划项目(BK20200266)。
关键词
急性缺血性脑卒中
静脉溶栓
高迁移率族蛋白B1
白细胞介素-8
炎症介质
预后
Acute ischemic stroke
Intravenous thrombolysis
High mobility group box 1
Interleukin-8
Inflammatory mediators
Clinical prognosis
