摘要
由于操作简便、成本低,结晶拆分目前仍然是工业上获得单一构型手性药物或其中间体的重要手段.基于“量身定制”添加剂的逆向结晶方法适用底物范围大,拆分效率高,应用前景广阔.本文重点介绍了逆向结晶过程中均聚物、共聚物、多糖衍生物、聚合物组装体以及高分子/纳米粒子杂化体系调控手性化合物立体选择性结晶的研究进展,讨论了聚合物添加剂的构效关系和高效回收策略,并对其今后发展提出一些看法.
Among chiral resolution methods,crystallization resolution is still a frequency used methods for obtaining enantiomerically pure chiral drugs or their intermediates in pharmaceutical industry owing to its simple operation and low cost.The reverse crystallization with the assistance of“tailor-made”additives is suitable for a wide range of substrates,shows high resolution efficiency,and has broad application prospects.Recent research advancements in the field of crystallization resolution using polymeroc additives have been comprehensively reviewed in this article.It includes homopolymers,copolymers,polysaccharide derivatives,polymer assemblies,and polymer/nanoparticle hybrids.In addition,the structure-activity relationship and efficient recovery strategy of the polymeric additives are discussed,and the future development of polymeric additives is proposed.
作者
王兆旭
陈艺夫
李婧
陶艺
刘应泽
叶曦翀
宛新华
Zhao-xu Wang;Yi-fu Chen;Jing Li;Yi Tao;Ying-ze Liu;Xi-chong Ye;Xin-hua Wan(Beijing National Laboratory for Molecular Sciences,Key Laboratory of Polymer Chemistry and Physics of Ministry of Education,College of Chemistry and Molecular Engineering,Peking University,Beijing 100871;Shanxi-Zheda Institute of Advanced Materials and Chemical Engineering,Taiyuan 030032;State Key Laboratory for Mechanical Behaviour of Materials,Shaanxi International Research Center for Soft Matter,School of Materials Science and Engineering,Xi’an Jiaotong University,Xi’an 710049)
出处
《高分子学报》
北大核心
2025年第8期1279-1292,共14页
Acta Polymerica Sinica
基金
国家自然科学基金(基金号52333008)
石家庄·北京大学合作专项、北京大学博雅博士后项目、北京分子科学研究中心BMS Junior Fellow项目
国家资助博士后研究人员计划(项目号GZC20230031)资助.
关键词
结晶拆分
“量身定制”添加剂
聚合物
手性药物
多糖衍生物
Chiral resolution
“Tailor-made”stereoselective additive
Polymer
Chiral drug
Polysaccharide derivative
