摘要
目的:探讨富马酸奥赛利定对重症肺炎患者镇痛镇静的效果。方法:选取2024年3月~2024年11月在信阳市中心医院ICU收治的行机械通气的重症肺炎患者48例为研究对象,随机分为对照组(n=20)与观察组(n=28)。对照组静脉泵注盐酸右美托咪定麻醉镇静,观察组静脉泵注富马酸奥赛利定麻醉镇静,记录两组患者机械通气时间、拔管时间与理想镇静时间,采用Richmond躁动-镇静评分(RASS)和重症监护疼痛观察量表(CPOT)评估患者状况,监测用药期间的不良反应情况。结果:①观察组患者的机械通气时间、拔管时间、达到理想镇静的时间均短于对照组,差异有统计学意义(P<0.05);②观察组患者在机械通气的第1天、第3天和第5天时,其CPOT评分均低于对照组,差异有统计学意义(P<0.05);③第3天与第5天时,观察组的RASS评分均低于对照组,差异有统计学意义(P<0.05);④观察组用药后有1例肺癌晚期合并糖尿病患者出现谵妄,其余患者无不良反应发生,且与对照组患者的不良反应发生率比较,差异有统计学意义(P<0.05)。结论:富马酸奥赛利定对重症肺炎患者有较好的镇痛镇静效果。
Objective To investigate the analgesic and sedative effects of fumarate oxalidomide on patients with severe pneumonia.Methods A total of 48 patients with severe pneumonia admitted to the ICU of Xinyang Central Hospital from March to November 2024 were selected and randomly divided into the control group(n=20)and the observation group(n=28).The control group was anesthetized and sedated by intravenous infusion of dexmedetomidine hydrochloride,and the observation group was anesthetized and sedated by intravenous infusion of Fumarate oxalidomide.The mechanical ventilation time,extubation time,and ideal sedation time were recorded,and the patient's condition was evaluated by the Richmond agitation-sedation score(RASS)and the critical care pain observation scale(CPOT).The adverse reactions during the drug administration were monitored.Results(1)The mechanical ventilation time in the observation group was shorter than that in the control group,and the difference was statistically significant(P<0.05).The extubation time in the observation group was also shorter than that in the control group,and the difference was statistically significant(P<0.05).The time to achieve ideal sedation in the observation group was shorter than that in the control group,and the difference was statistically significant(P<0.05).(2)The CPOT scores of the observation group patients on mechanical ventilation on the 1st,3rd,and 5th days were all lower than those of the control group(P<0.05).(3)The RASS scores of the observation group patients on the 3rd and 5th days were both lower than those of the control group(P<0.05).(4)After treatment,one patient with lung cancer in the observation group developed delirium,while no other adverse reactions occurred in the other patients.Compared with the control group,the incidence of adverse reactions in the observation group had a statistically significant difference(P<0.05).Conclusions Oxellidine fumarate has a better analgesic and sedative effect on patients with severe pneumonia.
作者
左玲
倪荣
何美子
苏叶子
王潘
ZUO Ling;NI Rong;HE Mei-Zi(Department of ICU,Xinyang Central Hospital,Xinyang 464000,Henan,China)
出处
《吉林医学》
2025年第8期1884-1887,共4页
Jilin Medical Journal
基金
四川省卫生健康委员会科技项目[项目编号:24WSXT097]。
关键词
富马酸奥赛利定
右美托咪定
重症肺炎
机械通气
治疗效果
Oxelidine fumarate
Dexmedetomidine
Severe pneumonia
Mechanical ventilation
Therapeutic effect
