摘要
依托咪酯具有显著的镇静效果,且具有良好的血流动力学特性和呼吸系统安全性,不会诱发心血管或呼吸抑制,因此依托咪酯被广泛用于休克、血流动力学不稳定、低血容量以及气道高反应性患者的全身麻醉诱导。近年来,依托咪酯在特殊患者麻醉维持中的作用逐渐受到关注,如老年患者、非心脏手术的心脏病患者、高血压患者、危重症患者、小儿患者。此外,依托咪酯作为类固醇生成酶抑制剂,主要通过抑制11β-羟化酶抑制皮质醇产生。基于此,越来越多的研究通过将镇静催眠和肾上腺素抑制药物作用进行解离,对依托咪酯除麻醉外的替代治疗作用进行开发。
Etomidate has significant sedative effects,good hemodynamic properties,and respiratory safety,without inducing cardiovascular or respiratory depression.Therefore,etomidate is widely used for general anesthesia induction in patients with shock,hemodynamic instability,low blood volume,and airway hyperresponsiveness.In recent years,the role of etomidate in anesthesia maintenance for special patients has gradually attracted attention,such as elderly patients,patients with heart disease who have not undergone cardiac surgery,patients with hypertension,critically ill patients,and pediatric patients.In addition,etomidate,as a steroidogenic enzyme inhibitor,mainly inhibits cortisol production by suppressing 11β-hydroxylase.Based on this,an increasing number of studies are developing alternative therapeutic effects of etomidate besides anesthesia by dissociating the sedative hypnotic and adrenergic inhibitory effects.
作者
杨冬芸
田诗意
田春
彭明清
YANG Dongyun;TIAN Shiyi;TIAN Chun;PENG Mingqing(Department of Anesthesiology,the Affiliated Yongchuan Hospital of Chongqing Medical University,Chongqing 402160,China)
出处
《医学综述》
2025年第15期1885-1890,共6页
Medical Recapitulate
关键词
麻醉
依托咪酯
麻醉维持
替代治疗
血流动力学
Anesthesia
Etomidate
Anesthesia maintenance
Alternative therapy
Hemodynamics
