摘要
过氧化物还原蛋白1(PRDX1)作为核心抗氧化酶,在多种消化道肿瘤(包括食管癌、结直肠癌、胃癌、肝癌和胰腺癌)中高表达,并与肿瘤分期、转移以及不良预后密切相关。PRDX1可能通过清除活性氧、激活致癌信号通路、抑制细胞凋亡以及调控肿瘤微环境等多重机制促进肿瘤的发生发展及治疗耐药。PRDX1的小分子抑制剂及其联合治疗在临床前模型中展现出显著的抗肿瘤活性。因此,深入研究PRDX1在消化道肿瘤中的作用和分子调控机制以及靶向PRDX1的治疗策略,可为PRDX1的临床转化研究提供理论支持。
Peroxiredoxin 1(PRDX1),as a core antioxidant enzyme,is overexpressed in various gastrointestinal tumors(including esophageal cancer,colorectal cancer,gastric cancer,liver cancer and pancreatic cancer)and is significantly associated with tumor staging,metastasis,and poor prognosis.PRDX1 promotes tumorigenesis,progression,and treatment resistance through multiple pathways,including scavenging reactive oxygen species,activating oncogenic signaling pathways,inhibiting apoptosis,and modulating the tumor microenvironment.Small-molecule inhibitors targeting PRDX1 and their combination therapies have demonstrated significant antitumor activity in preclinical models.Therefore,in-depth research on the role and molecular regulatory mechanisms of PRDX1 in gastrointestinal tumors,as well as PRDX1-targeted treatment strategies,can provide theoretical support for the clinical translation research of PRDX1.
作者
鲍文芳
申屠航笑
李砚东
陈敬德
BAO Wenfang;SHENTU Hangxiao;LI Yandong;CHEN Jingde(Department of Oncology,Shanghai East Hospital/East Hospital Affiliated to Tongji University,Shanghai 200120,China)
出处
《医学综述》
2025年第15期1819-1823,共5页
Medical Recapitulate
基金
上海市浦东新区卫生系统学科建设特色专病项目(PWZzb2022-08)。
关键词
消化道肿瘤
过氧化物还原蛋白1
活性氧
Gastrointestinal tumors
Peroxiredoxin 1
Reactive oxygen species
