蓝芩口服液联合常规西药对急性化脓性扁桃体炎患儿炎症指标及症状改善时间的影响

Effect of Lanqin oral liquid combined with conventional Western medicine on inflammatory indicators and symptom improvement time in children with acute suppurative tonsillitis

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摘要目的探究蓝芩口服液结合常规西药对急性化脓性扁桃体炎患儿炎症指标及症状改善时间的影响。方法选取2021年1月至2024年12月德兴市人民医院收治的急性化脓性扁桃体炎患儿60例,按照随机数字表法分为两组。对照组(n=30)予以常规西药(阿莫西林克拉维酸钾、地塞米松)治疗,在此基础上,观察组(n=30)联合蓝芩口服液治疗,两组均持续治疗5 d。对比两组临床疗效、症状改善时间、炎症指标以及不良反应发生情况。结果观察组临床总有效率为96.67%,高于对照组的73.33%,有统计学差异(P<0.05);观察组扁桃体肿大、咽痛、发热改善时间分别为(2.04±0.36)d、(1.73±0.32)d、(1.12±0.33)d,均短于对照组的(3.62±0.48)d、(2.95±0.72)d、(2.18±0.64)d,有统计学差异(P<0.001);治疗后,观察组白细胞介素-2(IL-2)为(8.59±1.01)g/L,较对照组[(5.12±0.4)g/L]高;白细胞计数(WBC)、C反应蛋白(CRP)、肿瘤坏死因子-α(TNF-α)水平分别为(8.01±1.06)×10^(9)/L、(17.53±3.11)mg/L、(1.13±0.14)g/L,均较对照组[(10.02±2.16)×10^(9)/L、(24.23±4.17)mg/L、(1.85±0.39)g/L]低,有统计学差异(P<0.001);两组不良反应无统计学差异(P>0.05)。结论蓝芩口服液联合常规西药治疗能够有效改善急性化脓性扁桃体炎患儿临床症状,减轻炎症反应,且不会增加药物不良反应发生率。 Objective To explore the effect of Lanqin oral liquid combined with conventional Western medicine on inflam-matory indicators and symptom improvement time in children with acute suppurative tonsillitis.Methods Sixty children with acute suppurative tonsillitis admitted to Dexing People's Hospital from January 2021 to December 2024 were selected and randomly di-vided into two groups using a random number table.The control group(n=30)received conventional Western medicine treat-ment(amoxicillin-clavulanate potassium and dexamethasone),while the observation group(n=30)received additional Lanqin oral liquid.Both groups were treated for 5 days.The clinical efficacy,duration of symptom alleviation,inflammatory markers,and incidence of adverse reactions were compared between the two groups.Results The total clinical effective rate of the observa-tion group was 96.67%,which was higher than the 73.33%of the control group,with statistical differences(P<0.05);The ob-servation group had shorter tonsil swelling improvement time[(2.04±0.36)d],sore throat improvement time[(1.73±0.32)d],and fever improvement time[(1.12±0.33)d]compared to those of the control group[(3.62±0.48)d,(2.95±0.72)d,(2.18±0.64)d],with statistical differences(P<0.001);After treatment,the observation group had a higher concentration of interleukin-2(IL-2)[(8.59±1.01)g/L]compared to that of the control group[(5.12±0.4)g/L].The white blood cell count(WBC)[(8.01±1.06)×10^(9)/L],C-reactive protein(CRP)[(17.53±3.11)mg/L],and tumor necrosis factor alpha(TNF-α)[(1.13±0.14)g/L]were all lower than those of the control group[(10.02±2.16)×10^(9)/L,(24.23±4.17)mg/L,and(1.85±0.39)g/L],with statistical differences(P<0.001);There was no significant difference in adverse reactions be-tween the two groups(P>0.05).Conclusion Lanqin oral liquid combined with conventional Western medicine can effectively improve clinical symptoms,reduce inflammatory responses in children with acute suppurative tonsillitis,and does not increase the incidence of adverse drug reactions.

作者徐群方本明金绍峰 XU Qun;FANG Benming;JIN Shaofeng(Department of Pediatrics,Dexing People's Hospital,Dexing Jiangxi 334200,China)

机构地区德兴市人民医院儿内科

出处《天津药学》 2025年第7期843-846,共4页 Tianjin Pharmacy

关键词急性化脓性扁桃体炎蓝芩口服液阿莫西林克拉维酸钾地塞米松炎症指标症状改善时间 Acute suppurative tonsillitis Lanqin oral liquid Amoxicillin-clavulanate potassium Dexamethasone Inflam-matory indicators Symptom improvement time

分类号 R725 [医药卫生—儿科]