摘要
目的 比较食管癌三维适形放疗与调强放疗物理计划的效果。方法 选择2020年1月—2022年12月本院收治的50例食管癌患者为研究对象,按照随机数字表法将其分为两组,每组25例。对照组采用三维适形放疗,观察组采用调强放疗物理计划。观察两组患者预防照射区与肿瘤区以及周围器官的照射情况,比较相关指标的差异性。结果 两组预防照射区95%处方放疗剂量计划靶区体积占比(V_(95))、100%处方放疗剂量计划靶区体积占比(V_(100))比较,差异无统计学意义(P>0.05);观察组放疗剂量均值(D_(mean))、100%靶区体积集聚放疗绝对照射总剂量(D100)、95%靶区体积集聚放疗绝对照射总剂量(D_(95))、105%处方放疗剂量计划靶区体积占比(V_(105))以及靶区放疗剂量非均匀指数(HI)均 优于对照组,差异有统计学意义(P<0.05)。两组肿瘤区D_(mean)、D100、D_(95)、V_(105)和V_(95)比较,差异无统计学意义(P>0.05);观察组V_(100)、HI均优于对照组,差异有统计学意义(P<0.05)。两组脊髓D_(mean)以及肺部40%处方放疗剂量计划靶区体积占比(V_(40))与D_(mean)比较,差异无统计学意义(P>0.05);观察组脊髓D100低于对照组,差异有统计学意义(P<0.05)。结论 食管癌患者采用三维适形放疗与调强放疗物理计划均可治疗,相较于三维适形放疗,调强放疗物理计划的各照射区剂量分布更为理想,其原发病灶的生物等效剂量高,能充分抑制肿瘤组织,使癌细胞得到有效灭杀。
Objective To compare the effect of three-dimensional metaphysical radiotherapy and strong radiotherapy programs in esophageal cancer.Methods The 50 patients with esophageal cancer patients received from January 2020 to December 2022 were selected as objects.Random digital tables were packed,each group of 25 cases.The control group uses a three-dimensional appropriate radiotherapy,and the observation group uses a strong radiotherapy physics plan.Observe the situation of the two groups of patients to prevent the irradiation area and the tumor area and the surrounding organic organs,compare the differences between DMEAN,D100,D_(95) and other indicators.Results There was no statistically significant difference(P>0.05)between the 95%prescription radiotherapy dose plan target volume proportion(V_(95))and the 100%prescription radiotherapy dose plan target volume proportion(V_(100))in the two groups of preventive irradiation areas;The mean radiation dose of the observation group(D_(mean)),absolute total radiation dose of 100%target volume aggregation radiation therapy(D100),absolute total radiation dose of 95%target volume aggregation radiation therapy(D_(95)),planned target volume proportion of 105%prescription radiation dose(V_(105)),and non-uniformity index of target radiation dose(HI)were all better than those of the control group,and the differences were statistically significant(P<0.05).There was no statistically significant difference in D_(mean),D100,D_(95),V_(105),and V_(95) between the two tumor regions(P>0.05);The observation group had better V_(100) and HI than the control group,and the difference was statistically significant(P<0.05).There was no statistically significant difference(P>0.05)in the proportion of target area volume(V_(40))between two groups of spinal cord D_(mean) and lung 40%prescription radiotherapy dose plan compared with D_(mean);The spinal cord D100 in the observation group was lower than that in the control group,and the difference was statistically significant(P<0.05).Conclusion Both patients with esophageal cancer adopt three-dimensional metaphysical radiotherapy and strong radiotherapy physics programs.Compared with three-dimensional appropriate radiotherapy,the dosage distribution of each irradiation area of strong radiotherapy programs is more ideal.High dosage can be fully suppressed by tumor tissue,so that cancer cells can be effectively killed.
作者
杨蒙
YANG Meng(A radiotherapy department of Chifeng Cancer Hospital,Chifeng,Inner Mongolia 024000)
出处
《智慧健康》
2025年第14期123-126,共4页
Smart Healthcare
关键词
食管癌
三维适形放疗
调强放疗物理计划
esophageal cancer
three-dimensional appropriate radiotherapy
strong radiotherapy programs
