摘要
目的探讨慢性自发性荨麻疹(CSU)患者血清脱氢表雄酮硫酸酯(DHEA-S)、免疫调节细胞因子与病情严重程度的关系。方法选取苏州大学附属第四医院皮肤医学美容科2023年1月至2024年12月30例慢性自发性荨麻疹患者为观察组,按照CSU病情分级标准分为轻度组、中度组和重度组,每组各10例;同时选取30名健康体检者作为对照组。比较观察DHEA-S、免疫调节细胞因子与病情严重程度和病程的相关性。结果观察组与对照组相比,血清25(OH)D、DHEA-S、IL-2、IFN-γ明显降低,IL-4、IgE、IgG升高(P<0.05),DHEA-S、IgE及IgG水平均有显著的不同(P<0.05);中度组、重度组DHEA-S较轻组明显降低,重度组较轻组明显降低(P<0.05);而中度、重度患者IgE、IgG水平明显增高,重度患者IgE、IgG水平明显升高(P<0.05)。结论DHEA-S、免疫调节细胞因子能够为CSU病程、病情严重程度提供准确预测价值,确保治疗方案更加科学。
Objective To investigate the relationship between serum dehydroepiandrosterone sulfate(DHEA-S),immunoregulatory cytokines,and disease severity in patients with chronic spontaneous urticaria(CSU).Methods A total of 30 patients with chronic spontaneous urticaria from the fourth affiliated hospital of Soochow University from January 2023 to December 2024 were selected.the Fourth Affiliated Hospital of Suzhou University were selected as the observation group,and were divided into mild group,moderate group and severe group according to CSU’s disease classification standard,with 10 patients in each group.At the same time,30 healthy people were selected as the control group,and the correlation between DHEA-S and immune regulatory cytokines and the severity and course of the disease was compared and observed.Results Compared with the control group,the observation group showed significantly lower serum levels of 25(OH)D,DHEA-S,IL-2,and IFN-γ,but higher levels of IL-4,IgE,and IgG(P<0.05).Statistically significant differences were observed in DHEA-S,IgE,and IgG levels(P<0.05).The moderate and severe subgroups exhibited lower DHEA-S levels than the mild subgroup,with the severe subgroup further showing lower DHEA-S than the moderate subgroup(P<0.05).Conversely,IgE and IgG levels in the moderate and severe subgroups were higher than those in the mild subgroup,with the severe subgroup demonstrating even higher levels than the moderate subgroup(P<0.05).Conclusions DHEA-S and immune regulatory cytokines levels can provide accurate predictive value for the disease course and severity of chronic spontaneous urticaria(CSU),thereby ensuring more scientific treatment strategies.
作者
李孟节
LI Mengjie(Department of Dermatology and Cosmetology,The Fourth Affiliated Hospital of Soochow University(Suzhou Dushu Lake Hospital),Suzhou,Jiangsu 215000)
出处
《中国医药指南》
2025年第20期106-108,共3页
Guide of China Medicine
