摘要
癌症是目前全球面临的最大公共卫生问题之一,手术切除、放疗、化疗和靶向治疗等传统治疗手段具有一定局限性。溶瘤病毒(oncolytic virus,OV)疗法作为新的免疫治疗手段在过去十几年里飞速发展,展现出较大的抗肿瘤潜力。通过对腺病毒进行复制修饰、靶向性修饰以及插入外源基因等策略的改造,可以使其成为具有更高肿瘤杀伤效应的溶瘤腺病毒(oncolytic adenovirus, OAd)。目前,OAd药物已在临床上被大量应用,本文将对OAd的现有改造策略、已批准上市药物及联合治疗策略进行归纳总结,探索OAd治疗癌症的新发展模式。
Cancer is one of the most significant public health challenges globally.Traditional treatment methods,such as surgical resection,radiotherapy,chemotherapy,and targeted therapy have certain limitations.Oncolytic virus(OV)therapy,as a new form of immunotherapy,has rapidly developed in the past decade,showcasing its significant anti-tumor potential.Oncolytic adenovirus(OAd)could be developed into a type of tumor-killing virus through replication modification,targeted modification,and the insertion of foreign genes.At present,OAd drugs have been widely used in clinical practice.This paper will summarize the existing modification strategies,approved drugs,and combined treatment strategies of OAd,and explore a new development model for OAd treatment in cancer.
作者
田文豪
邢涵雪
杨筱舟
陈琛
TIAN Wenhao;XING Hanxue;YANG Xiaozhou;CHEN Chen(Shaanxi Province Key Laboratory of Bio-resources,Qinba Mountain Area Collaborative Innovation Center of Bioresources Comprehensive Development,Qinba State Key Laboratory of Biological Resources and Ecological Environment(Incubation),College of Biological Science and Engineering,Shaanxi University of Technology,Hanzhong 723000,China)
出处
《中国现代应用药学》
北大核心
2025年第13期2330-2337,共8页
Chinese Journal of Modern Applied Pharmacy
基金
陕西理工大学校级科研项目人才启动基金(SLGRCQD2305)
汉中市2024年度科技计划项目(7)。
关键词
溶瘤病毒
腺病毒
癌症
基因修饰
联合治疗
oncolytic virus
adenovirus
cancer
gene modification
combination therapy
