摘要
目的 探讨丙戊酸钠和左乙拉西坦在治疗儿童癫病中的成本-效果,为临床用药提供经济学依据。方法 采用成本-效果分析方法,基于决策树模型,比较丙戊酸钠和左乙拉西坦在治疗儿童癫痫病中的有效率与药品成本。通过单因素敏感性分析和概率敏感性分析,评估各参数变动对研究结果的影响。结果 左乙拉西坦的治疗成本显著高于丙戊酸钠,左乙拉西坦和丙戊酸钠比较的增量成本-效果比(ICER)值为8 628.43元。敏感性分析与基础分析结果相一致,概率敏感性分析结果显示,基于6个月的治疗周期,当支付意愿为9 000元或以上时,左乙拉西坦是更为经济的方案。单因素敏感性分析显示,在影响ICER的各因素中,左乙拉西坦的价格为最敏感因素。结论 每治疗1例有效的儿童癫痫患者的支付意愿值在9 000元或以上时,左乙拉西坦更具有经济学优势。
Objective To compare the cost-effectiveness between sodium valproate and levetiracetam in the treatment of childhood epilepsy and provide an economic basis for clinical medication choices.Methods A cost-effectiveness analysis was conducted using a decision tree model to compare the effectiveness and drug costs of sodium valproate and levetiracetam in treating childhood epilepsy.Single-factor sensitivity analysis and probabilistic sensitivity analysis were used to assess the impact of parameter variations on the study results.Results The treatment cost of levetiracetam was significantly higher than that of sodium valproate.The incremental cost-effectiveness ratio(ICER)of levetiracetam compared to sodium valproate was¥8628.43.Sensitivity analysis results were consistent with the base-case analysis.The probabilistic sensitivity analysis showed that,over a 6-month treatment period,levetiracetam became a more cost-effective option when the willingness-to-pay(WTP)threshold was¥9,000 or higher.One-way sensitivity analysis revealed that the price of levetiracetam was the most influential factor affecting the ICER.Conclusion When the WTP per effective pediatric epilepsy case is¥9,000 or higher,levetiracetam demonstrates a cost-effectiveness advantage.
作者
邵尉
袁妮
刘叶
于飞
柳莹
王峰
SHAO Wei;YUAN Ni;LIU Ye;YU Fei;LIU Ying;WANG Feng(Liaoning Medical Vocational College,Shenyang 110101,China;Dalian Medical University,Dalian 116044,China;The Ninth People’s Hospital of Shenyang,Shenyang 110024,China)
出处
《药学实践与服务》
2025年第8期410-413,420,共5页
Journal of Pharmaceutical Practice and Service
基金
教育部产学合作协同育人项目(230905329045253)
辽宁省教育厅高校基本科研项目(LJ112414289003、LJ212414289009)
辽宁省生物医药创新发展人才研究会(LRAIDBT2401)
沈阳市社会科学课题(SYSK2024-01-130)。
